Results 11 to 20 of about 821,330 (390)

Triglyceride and Triglyceride-Rich Lipoproteins in Atherosclerosis

Frontiers in Molecular Biosciences, 2022
Cardiovascular disease (CVD) is still the leading cause of death globally, and atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol (LDL-C) is a strong causal factor of atherosclerosis. However, the first-line lipid-
Baihui Zhang, F. Yin, Yarong Qiao, Shou-Dong Guo   +3 more
semanticscholar   +4 more sources

Triglyceride Metabolism in the Liver.

Comprehensive Physiology, 2017
Triglyceride molecules represent the major form of storage and transport of fatty acids within cells and in the plasma. The liver is the central organ for fatty acid metabolism.
M. Alves‐Bezerra, D. Cohen
semanticscholar   +4 more sources

Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data

Cardiovascular Diabetology, 2023
Background The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated to predict cardiovascular disease (CVD).
Bizhong Che, C. Zhong, Ruijie Zhang, Liyuan Pu, Tian Zhao, Yonghong Zhang, L. Han   +6 more
semanticscholar   +1 more source

A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy

Molecular Genetics and Metabolism Reports, 2023
Primary triglyceride deposit cardiomyovasculopathy (P-TGCV), caused by a rare genetic mutation in PNPLA2 encoding adipose triglyceride lipase (ATGL), exhibits severe cardiomyocyte steatosis and heart failure. Here, we report the case of a 51-year-old man
Yasuhiro Hara, Yoshihiko Ikeda, Hayato Kimura, Shinsaku Shimamoto, Mao Ishikawa, Kunihisa Kobayashi, Hironori Nagasaka, Hisashi Shimoyama, Ken-ichi Hirano   +8 more
doaj   +1 more source

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Cardiovascular Diabetology, 2022
The triglyceride-glucose (TyG) index has been identified as a reliable alternative biomarker of insulin resistance (IR). Recently, a considerable number of studies have provided robust statistical evidence suggesting that the TyG index is associated with
Lichan Tao, Jia-ni Xu, Tingting Wang, Fei Hua, Jian Li   +4 more
semanticscholar   +1 more source

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.

New England Journal of Medicine, 2022
BACKGROUND High triglyceride levels are associated with increased cardiovascular risk, but whether reductions in these levels would lower the incidence of cardiovascular events is uncertain.
Aruna Das Pradhan, R. Glynn, J. Fruchart, Jean G Macfadyen, Elaine Zaharris, Brendan M. Everett, Stuart E. Campbell, Ryu Oshima, P. Amarenco, D. Blom, E. Brinton, R. Eckel, M. Elam, J. Felício, H. Ginsberg, A. Goudev, Shun Ishibashi, Jacob Joseph, T. Kodama, W. Koenig, L. Leiter, A. Lorenzatti, B. Mankovsky, N. Marx, B. Nordestgaard, D. Páll, K. Ray, Raul D. Santos, H. Soran, A. Susekov, M. Tendera, K. Yokote, N. Paynter, J. Buring, P. Libby, P. Ridker   +35 more
semanticscholar   +1 more source

Triglyceride cycling enables modification of stored fatty acids

Nature Metabolism, 2023
Triglyceride cycling is the process of continuous degradation and re-synthesis of triglyceride in cellular stores. We show in 3T3-L1 adipocytes that triglycerides are subject to rapid turnover and re-arrangement of fatty acids with an estimated half-life
Klaus Wunderling, Jelena Zurkovic, Fabian Zink, Lars Kuerschner, C. Thiele   +4 more
semanticscholar   +1 more source

Triglyceride Glucose (TyG) Index: A surrogate biomarker of insulin resistance.

JPMA. The Journal of the Pakistan Medical Association, 2022
The predictability of triglyceride glucose index (TyG index) as a biomarker for identification of insulin resistance (IR) is being extensively studied in various ethnic populations.
Vineetha K. Ramdas Nayak, Praseeda Satheesh, Mohan T Shenoy, Sanjay Kalra   +3 more
semanticscholar   +1 more source

Knockdown of lnc-KCNC3-3:1 Alleviates the Development of Atherosclerosis via Downregulation of JAK1/STAT3 Signaling Pathway

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis is a major cause of coronary artery disease (CAD), and CAD is one of the main causes leading to death in most countries. It has been reported that lncRNAs play important roles in the development of atherosclerosis; thus, we ...
Limin Sun, Xin He, Tao Zhang, Guizhou Tao, Xin Wang   +4 more
doaj   +1 more source

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking [PDF]

Open Biology, 2016
Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides (TG) into free fatty acids that are taken up by peripheral tissues.
Ren Zhang
doaj   +1 more source