Results 191 to 200 of about 487,969 (369)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Calcium absorption in the normal, bile-duct ligated, and cirrhotic rat, with observations on the effect of long- and medium-chain triglycerides. [PDF]

, 1968
A K Kehayoglou, H S Williams, W F Whimster, C D Holdsworth   +3 more
openalex   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

A Concept Formula With Large, Milk Phospholipid‐Coated Lipid Droplets Enriched With Milk Fat Decreases Palmitic Acid and Calcium Levels in Stools of Healthy, Term Infants

European Journal of Lipid Science and Technology, Volume 124, Issue 12, December 2022., 2022
Less formation of calcium soaps in infant formula containing (more) sn‐2 palmitate (PA) Top: pathway of sn‐1,3 PA, Bottom: pathway of sn‐2 PA Abstract This study evaluates the impact of an infant formula comprising large, dairy milk phospholipid‐coated lipid droplets containing a vegetable‐dairy lipid mixture (Concept‐Mix) with 6% of fatty acid (FA) as
Bert J. M. van de Heijning, Stefanie Schoen, Marieke Abrahamse‐Berkeveld, Anita C. S. Hokken‐Koelega, Eline M. van der Beek   +4 more
wiley   +1 more source

The Determination of Triglycerides in Plasma and Tissues [PDF]

, 1968
Vishwanath M. Sardesai, Joan A. Manning
openalex   +1 more source

Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis

Journal of Lipid Research, 2000
Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism, and has been hypothesized to exert either pro- or anti-atherogenic effects, depending on its localization. Decreased plasma LPL activity is associated with the high triglyceride (TG)–low
Susanne M. Clee, Nagat Bissada, Fudan Miao, Li Miao, A. David Marais, Howard E. Henderson, Pieternel Steures, Janet McManus, Bruce McManus, Renee C. LeBoeuf, John J.P. Kastelein, Michael R. Hayden   +11 more
doaj  

Asymmetric triglycerides from Impatiens edgeworthii seed oil

, 1967
M. O. Bagby, C. R. Smith
openalex   +1 more source

Very low density lipoproteins in intestinal lymph: role in triglyceride and cholesterol transport during fat absorption [PDF]

, 1969
Robert K. Ockner, Faith B. Hughes, Kurt J. Isselbacher   +2 more
openalex   +1 more source

Structural, Spectroscopic, and Docking Analysis of N,O‐Donor Ligand Metal Complex Nanoparticles With Hypolipidemic Effects via Lipoprotein Lipase Activation in High‐Fat Diet Mice

Chemistry &Biodiversity, EarlyView.
Hypolipidemic influence of CETZ.2HCl‐(H1‐antihistamine) metal‐complexes on “C57Bl/6‐mice” fed high‐fat‐diet. ABSTRACT New Cd(II), Zn(II), and Cu(II) chelates with cetirizine.2HCl (CETZ.2HCl) in incidence of 1,10 phenanthroline monohydrate (Phen.H2O) were synthesized in search of new biologically active compounds.
Sherif M. Abd El‐Hamid, Safa W. Aziz, Amira A. Mohamed, Mohammed S. El‐Gedamy, Ahmed E. Salem, Soha F. Mohammed, Wael A. Zordok, Adriano Sofo, Mohamed A. Sabry, Sadeek A. Sadeek, Hazem S. Elshafie   +10 more
wiley   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

ChemBioChem, EarlyView.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda, Mario van der Stelt, Sander Izaak van Kasteren   +2 more
wiley   +1 more source