Results 201 to 210 of about 725,613 (387)

GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity

open access: yesAdvanced Science, EarlyView.
This study leverages NHANES data to analyze 49 routine indicators, identifying the top 10 diagnostic markers for five major diseases and introducing GLM7, a novel indicator. Restricted cubic spline analyses, forest plot evaluations, and XGBoost modeling demonstrate conventional indicators' efficacy and GLM7's value for disease diagnosis/prediction ...
Zhihua Wang   +8 more
wiley   +1 more source

The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp.

open access: yesJournal of Clinical Endocrinology and Metabolism, 2010
F. Guerrero‐Romero   +7 more
semanticscholar   +1 more source

Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases

open access: yesAdvanced Science, EarlyView.
This study analyzes 398 432 participants, identifying four distinct metabolic‐inflammatory subtypes. These subtypes show a significant association with digestive disease risk. Cluster‐associated metabolite signatures partially explain this link. Machine learning models using these metabolites accurately predict risk for ten digestive diseases. Key risk
Zhenhe Jin   +10 more
wiley   +1 more source

A Multicenter Validation of a Fully Automated Chemiluminescence Immunoassay for Plasma Elafin in Psoriasis Diagnosis and Severity Assessment

open access: yesAdvanced Science, EarlyView.
The fully automated CLIA demonstrates high sensitivity and specificity for plasma Elafin, achieving 88% diagnostic accuracy and an AUC of 0.92 for psoriasis detection in a multicenter cohort. The assay reliably distinguishes psoriasis from other dermatoses, objectively stratifies disease severity, and allows longitudinal monitoring, supporting its ...
Jingkun Yi   +8 more
wiley   +1 more source

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

open access: yesNature Genetics, 2008
S. Kathiresan   +29 more
semanticscholar   +1 more source

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