Results 71 to 80 of about 487,969 (369)

Conching chocolate: A prototypical transition from frictionally jammed solid to flowable suspension with maximal solid content [PDF]

, 2019
The mixing of a powder of 10-50{\mu}m primary particles into a liquid to form a dispersion with the highest possible solid content is a common industrial operation. Building on recent advances in the rheology of such 'granular dispersions', we study a paradigmatic example of such powder incorporation: the conching of chocolate, in which a homogeneous ...
arxiv   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Common variants associated with plasma triglycerides and risk for coronary artery disease

Nature Genetics, 2013
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD).
Ron Do, C. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, G. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, Jin Chen, Martin L. Buchkovich, S. Mora, Jacques S. Beckmann, J. Bragg-Gresham, Hsing-Yi Chang, A. Demirkan, H. M. Hertog, L. Donnelly, G. Ehret, T. Esko, M. Feitosa, T. Ferreira, K. Fischer, P. Fontanillas, Ross M. Fraser, Daniel F. Freitag, D. Gurdasani, K. Heikkilä, Elina Hyppönen, A. Isaacs, A. Jackson, Å. Johansson, T. Johnson, M. Kaakinen, Johannes Kettunen, Johannes Kettunen, M. Kleber, Xiaohui Li, J. Luan, L. Lyytikäinen, P. Magnusson, M. Mangino, E. Mihailov, M. Montasser, Martina Müller-Nurasyid, I. Nolte, J. O’Connell, Cameron D. Palmer, M. Perola, M. Perola, M. Perola, A. Petersen, S. Sanna, R. Saxena, Sonia Shah, D. Shungin, C. Sidore, C. Song, R. Strawbridge, I. Surakka, I. Surakka, Toshiko Tanaka, Tanya M. Teslovich, G. Thorleifsson, E. V. D. Herik, B. Voight, K. Volcik, L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, D. Absher, G. Asiki, I. Barroso, L. Been, J. Bolton, L. Bonnycastle, P. Brambilla, M. Burnett, G. Cesana, M. Dimitriou, A. Doney, A. Döring, P. Elliott, Stephen E. Epstein, G. Eyjolfsson, B. Gigante, M. Goodarzi, H. Grallert, Martha L. Gravito, C. Groves, G. Hallmans, Anna-Liisa Hartikainen, C. Hayward, Dena G. Hernandez, Andrew A. Hicks, H. Hólm, Y. Hung, T. Illig, Michelle R Jones, P. Kaleebu, J. Kastelein, K. Khaw, Eric Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimäki, Shih-Yi Lin, J. Lindström, Ruth J. F. Loos, François Mach, W. McArdle, C. Meisinger, Braxton D. Mitchell, Gabrielle Müller, R. Nagaraja, Narisu Narisu, T. Nieminen, R. Nsubuga, I. Olafsson, Ken K Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, A. Pouta, Daniel J. Rader, M. Reilly, P. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, Janet Seeley, K. Silander, K. Silander, A. Stančáková, K. Stirrups, A. Swift, L. Tiret, A. Uitterlinden, L. J. V. Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, Sarah H Wild, G. Willemsen, T. Wilsgaard, James F. Wilson, E. Young, Jinghua Zhao, Linda S. Adair, D. Arveiler, T. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B. Boehm, D. Boomsma, I. Borecki, S. Bornstein, P. Bovet, M. Burnier, Harry Campbell, A. Chakravarti, J. Chambers, Y. I. Chen, F. Collins, Richard S. Cooper, J. Danesh, G. Dedoussis, U. Faire, A. Feranil, J. Ferrières, L. Ferrucci, N. Freimer, C. Gieger, L. Groop, V. Gudnason, U. Gyllensten, Anders Hamsten, T. Harris, A. Hingorani, J. Hirschhorn, A. Hofman, G. K. Hovingh, C. Hsiung, Steve E. Humphries, S. Hunt, K. Hveem, C. Iribarren, M. Järvelin, A. Jula, M. Kähönen, J. Kaprio, J. Kaprio, Antero Y. Kesäniemi, M. Kivimäki, J. Kooner, P. Koudstaal, R. Krauss, D. Kuh, J. Kuusisto, K. Kyvik, M. Laakso, T. Lakka, L. Lind, C. Lindgren, Nicholas G. Martin, Winfried März, M. I. McCarthy, C. McKenzie, P. Meneton, A. Metspalu, L. Moilanen, Andrew D. Morris, P. Munroe, I. Njølstad, Nancy L Pedersen, C. Power, P. Pramstaller, Jackie F. Price, B. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D. Sanghera, J. Saramies, Peter E. H. Schwarz, Wayne Huey-Herng Sheu, A. Shuldiner, A. Siegbahn, T. Spector, K. Stefansson, David P. Strachan, B. Tayo, E. Tremoli, J. Tuomilehto, Matti Uusitupa, C. Duijn, P. Vollenweider, L. Wallentin, N. Wareham, J. Whitfield, B. Wolffenbuttel, D. Altshuler, J. Ordovás, E. Boerwinkle, Colin N. A. Palmer, U. Thorsteinsdóttir, D. Chasman, Jerome I. Rotter, P. Franks, S. Ripatti, L. Cupples, M. Sandhu, S. Rich, M. Boehnke, P. Deloukas, K. Mohlke, E. Ingelsson, G. Abecasis, M. Daly, B. Neale, S. Kathiresan   +268 more
semanticscholar   +1 more source

Remnant Lipoprotein Cholesterol and Incident Coronary Heart Disease: The Jackson Heart and Framingham Offspring Cohort Studies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundRemnant lipoproteins (RLPs), the triglyceride‐enriched precursors to low‐density lipoprotein, are an emerging risk factor for coronary heart disease (CHD).
Parag H. Joshi, Arif A. Khokhar, Joseph M. Massaro, Seth T. Lirette, Michael E. Griswold, Seth S. Martin, Michael J. Blaha, Krishnaji R. Kulkarni, Adolfo Correa, Ralph B. D'Agostino, Steven R. Jones, Peter P. Toth   +11 more
doaj   +1 more source

Integrated systems approach identifies pathways from the genome to triglycerides through a metabolomic causal network [PDF]

arXiv, 2018
Introduction: To leverage functionality and clinical relevance into understanding systems biology, one needs to understand the pathway of the genetic effects on risk factors/disease through intermediate molecular levels, such as metabolomics. Systems approaches integrate multi-omic information to find pathways to disease endpoints and make optimal ...
arxiv  

A Pilot Clinical Study to Investigate the Human Whole Blood Spectrum Characteristics in the Sub-THz Region [PDF]

, 2014
We have conducted a pilot clinical study to not only investigate the THz spectra of ex-vivo fresh human whole blood of 28 patients following 8-hours fasting guideline, but also to find out the critical blood ingredients of which the concentration dominantly affects those THz spectra.
arxiv   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Isolation and characterization of four lipolytic preparations from rat skeletal muscle

Journal of Lipid Research, 1968
Four different lipolytic preparations have been isolated from rat skeletal muscle. Two of these, provisionally designated monopalmitin lipase (MPL) and monomyristin lipase (MML), are associated with insoluble cellular particulate fractions. The other two
Donald P. Wallach
doaj  

Genetics of Triglycerides and the Risk of Atherosclerosis

Current Atherosclerosis Reports, 2017
Purpose of ReviewPlasma triglycerides are routinely measured with a lipid profile, and elevated plasma triglycerides are commonly encountered in the clinic.
J. Dron, R. Hegele
semanticscholar   +1 more source