Results 1 to 10 of about 5,894 (213)

Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia [PDF]

Journal of Family Medicine and Primary Care
Anticholinergic drugs are extensively employed in clinical settings, with their side effects well-documented. However, paradoxical bradycardia due to trihexyphenidyl hydrochloride, an anticholinergic agent, is an infrequent and underreported phenomenon ...
Soumi Kundu, R. G. Medhagopal, Sarthak Das, Saroj K. Tripathy, Sarbari Sarkar, Md E. Ansari, Archana Malik   +6 more
doaj   +2 more sources

Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia

Neurobiology of Disease, 2019
Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M Downs, H A Jinnah, Ellen J Hess   +2 more
exaly   +3 more sources

Severity and influencing factors of hyperprolactinemia in hospitalized schizophrenia patients: a cross-sectional study [PDF]

Frontiers in Psychiatry
ObjectiveTo investigate the severity and influencing factors of hyperprolactinemia (HPRL) in hospitalized schizophrenia patients.MethodsThis retrospective study enrolled schizophrenia inpatients from a tertiary psychiatric hospital (2022-2023) with ...
Yan Yang, Yan Yang, Li Li, Li Li, Mi Yang, Mi Yang   +5 more
doaj   +2 more sources

Efficacy of Madopar and trihexyphenidyl combination therapy for dystonia in children with cerebral palsy [PDF]

Frontiers in Neurology
IntroductionDystonia is a predominant and debilitating movement disorder associated with dyskinetic cerebral palsy (DCP). Although trihexyphenidyl (THP) is commonly used as a treatment, its efficacy often exhibits a plateau effect.
Xiaolin Zhou, Xiangyang Luo, Zhanwen He, Mujin Liu, Pinggan Li   +4 more
doaj   +2 more sources

Protective role of coenzyme Q10 against trihexyphenidyl-induced pulmonary toxicity in Wistar rats [PDF]

BMC Pharmacology and Toxicology
Background Trihexyphenidyl (THP), an anticholinergic drug used to manage Parkinson’s disease and dystonia, has been associated with oxidative stress and metabolic disturbances, particularly affecting pulmonary function.
Joseph Gbenga Omole, Lydia Oluwatoyin Ajayi, Itunuoluwa Rachael Ajewole, Teniola Osholonge, Oyedayo Phillips Akano, Ayodeji Folorunsho Ajayi   +5 more
doaj   +2 more sources

The clinical characteristics, putative drugs, and optimal management of 62 patients with stevens-johnson syndrome and/or toxic epidermal necrolysis: A retrospective observational study

Indian Dermatology Online Journal, 2022
Background: Case reviews of severe cutaneous adverse drug reactions (ADRs) such as SJS/TEN provide useful insights for clinical characteristics, putative drugs, and management protocols.
Sujaya Manvi, Vikram K Mahajan, Karaninder S Mehta, Pushpinder S Chauhan, Sanket Vashist, Ravinder Singh, Prabal Kumar   +6 more
doaj   +1 more source

Treatment of Dystonia Using Trihexyphenidyl in Costello Syndrome

Brain Sciences, 2020
Costello syndrome (CS), a rare syndrome with multisystemic involvement inherited as a dominant trait, is characterized by developmental delay, coarse facial appearance, cardiac defects including hypertrophic cardiomyopathy, skin abnormalities, brain ...
Domenico M. Romeo, Alessandro Specchia, Alfonso Fasano, Chiara Leoni, Roberta Onesimo, Claudia Brogna, Stefania Veltri, Giuseppe Zampino   +7 more
doaj   +1 more source

Crystal structures of four organic salts of trihexyphenidyl at 90 K

Acta Crystallographica Section E: Crystallographic Communications, 2023
The syntheses and crystal structure studies of four organic salts of trihexyphenidyl, viz., trihexyphenidylium [1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidin-1-ium] 4-nitrobenzoate, C20H32NO+·C7H4NO4− (I), trihexyphenidylium 4-hydroxybenzoate ...
Vinaya, Yeriyur B. Basavaraju, Hemmige S. Yathirajan, Sean Parkin   +3 more
doaj   +1 more source

Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson’s disease patients

BMC Neurology, 2022
Background Parkinson’s disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids (SCFAs), derived from gut microbiota, are supposed to anticipate PD pathogenesis via the pathway of spinal ...
Gang Wu, Zhengli Jiang, Yaling Pu, Shiyong Chen, Tingling Wang, Yajing Wang, Xiaoping Xu, Shanshan Wang, Minya Jin, Yangyang Yao, Yang Liu, Shaofa Ke, Suzhi Liu   +12 more
doaj   +1 more source

Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, Jürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia   +10 more
wiley   +1 more source