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Effect of transcranial magnetic stimulation on focal hand dystonia: a systematic review and meta-analysis [PDF]
DystoniaBackgroundFocal hand dystonia (FHD) is a rare and disabling movement disorder with limited treatment options. Transcranial magnetic stimulation (TMS) has shown promise as a non-invasive neuromodulation therapy for dystonia, but its efficacy in FHD ...
Zeynep B. Simsek +9 more
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Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment [PDF]
DystoniaDystonia is a complex neurological disorder characterized by sustained or intermittent abnormal movements and/or postures. However, dystonia’s non-motor symptoms, particularly the sleep disturbances, are critical yet underexplored concerns that affect ...
Linda H. Kim +11 more
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Video analysis of patients with blepharospasm and lower face dystonias
Dystonia, 2023 Background: Blepharospasm (BSP) is a focal dystonia. There is a lack of standardization in the length of time necessary to get a measure of BSP severity for rating scales.Objectives: 1) Determine the difference between evaluating the number of eye ...
Mahdieh Hosseini +4 more
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Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice
Dystonia, 2023 Although dystonia is the third most common movement disorder, patients often also experience debilitating nonmotor defects including impaired sleep.
Luis E. Salazar Leon +7 more
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Dystonia, 2023 Background: Bradykinesia has been reported in patients with dystonia. Despite this, the pathophysiological mechanisms of bradykinesia in dystonia remain largely unknown.Methods: We here performed a comprehensive literature search and reviewed clinical ...
Giulia Paparella +10 more
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Gait and balance in cervical dystonia and dystonic head tremor
Dystonia, 2023 Background: Previous studies have found gait and balance abnormalities in patients with cervical dystonia. However, the characteristics of gait and balance in cervical dystonia with head tremors have not been ascertained.
Aparna Wagle Shukla +2 more
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Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia
Dystonia, 2023 Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden +6 more
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Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.
Frontiers in Cellular Neuroscience, 2013 Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura +9 more
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Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells
Disease Models & Mechanisms, 2016 X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito +12 more
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Frontiers in Neuroanatomy, 2015 Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto +6 more
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