Results 1 to 10 of about 52,972 (303)

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Frontiers in Cellular Neuroscience, 2013
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto   +9 more
doaj   +1 more source

Service-based survey of dystonia in Munich [PDF]

, 2002
We performed a service-based epidemiological study of dystonia in Munich, Germany. Due to favourable referral and treatment patterns in the Munich area, we could provide confident data from dystonia patients seeking botulinum toxin treatment.
Gasser, T., Y. Ben-Shlomo, B. Conrad, Ceballos-Baumann, Andres, E. Castelon Konkiewitz, Warner, T., T. Warner, T. Gasser, I. Trender-Gerhard, Ben-Shlomo, Y., C. Kamm, A.O. Ceballos-Baumann, Konkiewitz, E. C., Trender-Gerhard, I., Conrad, B., Kamm, C.   +15 more
core   +1 more source

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells

Disease Models & Mechanisms, 2016
X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito, William T. Hendriks, Jyotsna Dhakal, Christine A. Vaine, Christina Liu, David Shin, Kyle Shin, Noriko Wakabayashi-Ito, Marisela Dy, Trisha Multhaupt-Buell, Nutan Sharma, Xandra O. Breakefield, D. Cristopher Bragg   +12 more
doaj   +1 more source

Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains

Frontiers in Neuroanatomy, 2015
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto, Satoshi eGoto, Satoshi eGoto, Ryoma eMorigaki, Shinya eOkita, Shinji eNagahiro, Ryuji eKaji   +6 more
doaj   +1 more source

Anatomical categorization of isolated non-focal dystonia: novel and existing patterns using a data-driven approach

Dystonia, 2023
According to expert consensus, dystonia can be classified as focal, segmental, multifocal, and generalized, based on the affected body distribution. To provide an empirical and data-driven approach to categorizing these distributions, we used a data ...
J. R. Younce, R. H. Cascella, B. D. Berman, H. A. Jinnah, H. A. Jinnah, S Bellows, J. Feuerstein, A. Wagle Shukla, A. Mahajan, F. C. F. Chang, K. R. Duque, S. Reich, S. Pirio Richardson, A. Deik, N. Stover, J. M. Luna, S. A. Norris, S. A. Norris   +17 more
doaj   +1 more source

Long-Term Efficacy and Safety of Chronic Globus Pallidus Internus Stimulation in Different Types of Primary Dystonia [PDF]

, 2009
Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a
Voges, J., Steude, U., Zeitler, K., Sturm, V., Bötzel, Kai, Mehrkens, Jan Hinnerk, Schnitzler, A.   +6 more
core   +1 more source

Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.

Frontiers in Neuroanatomy, 2016
Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
doaj   +1 more source

Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process

Dystonia, 2023
Background: Botulinum toxin (BoNT) injections have been found to improve pain symptoms of isolated cervical dystonia (CD). In addition to muscle relaxation at the peripheral level, few studies suggest that BoNT has effects on the central brain ...
Aparna Wagle Shukla, Robert Chen, Wei Hu
doaj   +1 more source

Focal Dystonia: The Root Causes Underpinning the Yips [PDF]

, 2021
Cases of the yips have popped up from time to time in all different sports from MLB pitchers suddenly not being able to find the strike zone to professional golfers missing very short putts. A theory proposed by researchers to explain the yips is a motor
Rhoads, Brigham, Nghe, Amy, Martin, Georgia, Gibson, Eve, Loeb, Rachael, Sprague, Samuel   +5 more
core   +1 more source

The role of protein kinase R in dystonia

Dystonia, 2023
Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd, Benjamin Dodd, Stephanie L. Moon, Stephanie L. Moon   +3 more
doaj   +1 more source