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The role of protein kinase R in dystonia
Dystonia, 2023 Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd +3 more
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A History of Dystonia: Ancient to Modern [PDF]
, 2017 Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to ...
Deborah Thorpe +3 more
core +1 more source
Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Brain Sciences, 2017 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
doaj +1 more source
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
Neurobiology of Disease, 2017 X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine +7 more
doaj +1 more source
Dystonia, 2023 Task-specific tremor (TST) is a specific type of tremor that occurs when performing or attempting to perform a specific task, such as writing or playing a musical instrument. The clinical entity of TST remains heterogeneous. Some TSTs can only be induced
Yih-Chih Jacinta Kuo +1 more
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Regaining Motor Control in Musician's Dystonia by Restoring Sensorimotor Organization [PDF]
, 2009 Professional musicians are an excellent human model of long term effects of skilled motor training on the structure and function of the motor system.
Butler, K +3 more
core +1 more source
Dystonia, 2023 Advances in sequencing technologies have identified novel genes associated with inherited forms of dystonia, providing valuable insights into its genetic basis and revealing diverse genetic pathways and mechanisms involved in its pathophysiology.
Dhananjay Yellajoshyula
doaj +1 more source
Testing rTMS-Induced Neuroplasticity: A Single Case Study of Focal Hand Dystonia [PDF]
, 2018 Focal hand dystonia in musicians is a neurological motor disorder in which aberrant plasticity is caused by excessive repetitive use. This work's purposes were to induce plasticity changes in a dystonic musician through five daily thirty-minute sessions ...
Betti, Sonia +3 more
core +6 more sources
Early Globus Pallidus Internus Stimulation in Pediatric Patients With Generalized Primary Dystonia: Long-Term Efficacy and Safety [PDF]
, 2010 Primary generalized dystonia presents mainly at a young age and commonly is severely disabling. The authors report the long-term follow-up (mean, 73 months; range, 50-101 months) of 5 pediatric patients (mean age at surgery 13 years; range, 8-16 years ...
Berend Feddersen +6 more
core +1 more source
Clinical Case Reports, 2018 Key Clinical Message Tardive dystonia is a risk factor in medical antipsychotic treatment. It often begins with repetitive involuntary jaw and tongue movements resulting in impaired chewing and detrimental effect on the dentition.
Merete Bakke +4 more
doaj +1 more source