Results 21 to 30 of about 59,501 (281)
Long-Term Efficacy and Safety of Chronic Globus Pallidus Internus Stimulation in Different Types of Primary Dystonia [PDF]
, 2009 Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a
Voges, J. +6 more
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Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.
Frontiers in Neuroanatomy, 2016 Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
doaj +1 more source
Schizophrenia Bulletin, 1999 This paper provides an overview of the phenomenology, epidemiology, and treatment of tardive dystonia. Tardive dystonia is one of the extrapyramidal syndromes that starts after long-term use of dopamine receptor antagonists. The diagnosis is based on the presence of chronic dystonia, defined as a syndrome of sustained muscle contractions, frequently ...
van Harten, P.N., Kahn, R.S.
openaire +3 more sources
Dystonia, 2023 According to expert consensus, dystonia can be classified as focal, segmental, multifocal, and generalized, based on the affected body distribution. To provide an empirical and data-driven approach to categorizing these distributions, we used a data ...
J. R. Younce +17 more
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Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Brain Sciences, 2017 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
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Dystonia, 2023 Background: Botulinum toxin (BoNT) injections have been found to improve pain symptoms of isolated cervical dystonia (CD). In addition to muscle relaxation at the peripheral level, few studies suggest that BoNT has effects on the central brain ...
Aparna Wagle Shukla, Robert Chen, Wei Hu
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Early Globus Pallidus Internus Stimulation in Pediatric Patients With Generalized Primary Dystonia: Long-Term Efficacy and Safety [PDF]
, 2010 Primary generalized dystonia presents mainly at a young age and commonly is severely disabling. The authors report the long-term follow-up (mean, 73 months; range, 50-101 months) of 5 pediatric patients (mean age at surgery 13 years; range, 8-16 years ...
Feddersen, Berend +4 more
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X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
Neurobiology of Disease, 2017 X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine +7 more
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The role of protein kinase R in dystonia
Dystonia, 2023 Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd +3 more
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Age-related Sexual Dimorphism in Temporal Discrimination and in Adult-onset Dystonia Suggests GABAergic Mechanisms [PDF]
, 2015 Background: Adult onset isolated focal dystonia presenting in early adult life is more frequent in men whereas in middle age it is female predominant.
Daniel G. Healy (12583432) +59 more
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