Results 71 to 80 of about 4,789,934 (292)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Automation of conceptual design and modification of aircraft-type unmanned aerial vehicles using multidisciplinary optimization and evolutionary algorithms. Part 2: results and analysis

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение
An example of practical application of the methodology of multidisciplinary optimization of the concept parameters of aircraft-type flight vehicles is considered in the form of solving the problem of modifying two existing aircraft with characteristics ...
V. A. Komarov, O. E. Lukyanov, V. H. Hoang, E. I. Kurkin, J. G. Quijada Pioquinto   +4 more
doaj   +1 more source

A hydrodynamic optimization design methodology for a ship bulbous bow under multiple operating conditions

Engineering Applications of Computational Fluid Mechanics, 2016
The main objective of this article is to describe an innovative methodology for the hydrodynamic optimization of a ship bulbous bow which considers multiple operating conditions.
Yu Lu, Xin Chang, An-kang Hu
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Simplified and flexible coils for stellarators using single-stage optimization [PDF]

Physics of Plasmas
Single-stage optimization, also known as combined plasma-coil algorithms or direct coil optimization, has recently emerged as a possible method to expedite the design of stellarator devices by including, in a single step, confinement, stability, and ...
R. Jorge, A. Giuliani, J. Loizu
semanticscholar   +1 more source

Trim turnpikes for optimal control problems with symmetries

Mathematics of Control, Signals, and Systems
Abstract Motivated by mechanical systems with symmetries, we focus on optimal control problems possessing certain symmetries. Following recent works (Faulwasser in Math Control Signals Syst 34:759–788 2022; Trélat in Math Control Signals Syst 35:685–739 2023), which generalized the classical concept of static turnpike to manifold turnpike we ...
Flaßkamp, Kathrin, Maslovskaya, Sofya, Ober-Blöbaum, Sina, Wembe, Boris   +3 more
openaire   +2 more sources

On the optimal trimming of high-throughput mRNA sequence data [PDF]

Frontiers in Genetics, 2013
AbstractThe widespread and rapid adoption of high-throughput sequencing technologies has afforded researchers the opportunity to gain a deep understanding of genome level processes that underlie evolutionary change, and perhaps more importantly, the links between genotype and phenotype.
openaire   +4 more sources

Dense Nanofibrillar Collagen–Silica Hybrids with High Strength and ECM‐Mimetic Tissue Integration

Advanced Functional Materials, EarlyView.
Dense nanofibrillar collagen–silica hybrids are engineered by synchronizing collagen fibrillogenesis with silica condensation, producing printable scaffolds that unexpectedly approach native extracellular matrix organization and strength. These cell‐free constructs guide endogenous cell‐infiltration, enable localized matrix remodeling, and integrate ...
Norein Norein, Shima Tavakoli, Philipp Wolf, Xie Ling, Veronica Rondahl, Klaus Leifer, Gry Hulsart‐Billström, Jöns Hilborn   +7 more
wiley   +1 more source

Matching of turn pattern measurements for cyclotrons using multiobjective optimization

Physical Review Accelerators and Beams, 2019
The usage of numerical models to study the evolution of particle beams is an essential step in the design process of particle accelerators. However, uncertainties of input quantities such as the beam energy and magnetic field lead to simulation results ...
Matthias Frey, Jochem Snuverink, Christian Baumgarten, Andreas Adelmann   +3 more
doaj   +1 more source