Results 31 to 40 of about 576 (158)

Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity [PDF]

, 2018
Transfusion of red cell concentrates (RCCs) is associated with increased risk of adverse outcomes that may be affected by different blood manufacturing methods and the presence of extracellular vesicles (EVs).
Acker, Jason P., Almizraq, Ruqayyah J., Inglis, Heather, Juffermans, Nicole, Menocha, Somaang, Muszynski, Jennifer A., Norris, Philip J., Pandey, Suchitra, Spinella, Philip C., Wirtz, Mathijs R.   +9 more
core   +3 more sources

Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells

The Journal of Physiology, Volume 600, Issue 23, Page 5027-5054, 1 December 2022., 2022
Abstract figure legend Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells eliminate cancer cells. At high killer‐to‐cancer cell ratios (left row), CTL or NK cells eliminate all melanoma cells, indicating that melanoma cells are initially not resistant to either CTL‐ or NK cell‐mediated cytotoxicity.
Kim S. Friedmann, Lea Kaschek, Arne Knörck, Sabrina Cappello, Niklas Lünsmann, Nadja Küchler, Cora Hoxha, Gertrud Schäfer, Sandra Iden, Ivan Bogeski, Carsten Kummerow, Eva C. Schwarz, Markus Hoth   +12 more
wiley   +1 more source

Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media. [PDF]

, 2015
Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications ...
Hommes, Daniel W, Lacey, Precious N, Manansala, Aida-Rae, Oikonomopoulos, Angelos, Tomakili, Tamera A, van Deen, Welmoed K, Ziman, Alyssa   +6 more
core   +3 more sources

A method based on plateletpheresis to obtain functional platelet, CD3+ and CD14+ matched populations for research immunological studies

Clinical &Experimental Allergy, Volume 52, Issue 10, Page 1157-1168, October 2022., 2022
We describe a platelet isolation method based on plateletpheresis that allows to obtain pure, highly concentrated and functional platelet samples from a single donor. Additionally, matched CD3+ and CD14+ populations can be obtained from a waste product of plateletpheresis procedure. All the samples are suitable for omics studies. Abstract Background In
Carmela Pablo‐Torres, María Isabel Delgado‐Dolset, Javier Sanchez‐Solares, Leticia Mera‐Berriatua, Lucía Núñez Martín Buitrago, Mar Reaño Martos, José Luis Bueno, Maria M. Escribese, Domingo Barber, Cristina Gomez‐Casado   +9 more
wiley   +1 more source

Comparative Evaluation of Single-donor Plateletpheresis using Haemonetics® MCS® Plus and Trima Accel®: A Retrospective Study from a Tertiary Cancer Centre, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Single-Donor Platelets (SDPs) collected through automated apheresis systems are essential for transfusion support in thrombocytopenic patients.
Lekshmi Sudev, K Vijayalakshmi
doaj   +1 more source

Human T‐lymphotropic virus in Irish blood donors: Impact on future testing strategy

Transfusion, Volume 62, Issue 9, Page 1799-1807, September 2022., 2022
Abstract Aim A risk‐based approach to the testing of blood donations for Human T‐Lymphotropic Virus (HTLV) should include an assessment of blood donation seroepidemiology. The objectives of the present study were to determine the proportion of HTLV positive units in Irish blood donations, and subsequently, to estimate the current risk of transfusion ...
Pádraig Williams, Niamh O'Flaherty, Stephen Field, Allison Waters   +3 more
wiley   +1 more source

Persistent aggregates in apheresis platelet concentrates are commonly collected from donors with a history of aggregate donation [PDF]

, 2016
Platelet apheresis sometimes causes persistent aggregates (PA). This study (n = 211) shows that changing the apheresis settings to reach fixed product volumes instead of yields does not influence PA incidence, even though PA products on average contain ...
Coene, J, Compernolle, Veerle, Feys, Hendrik, Pottel, H, Vandekerckhove, Philippe, Vandewalle, G   +5 more
core   +2 more sources

Total platelet donation count and donation frequency are determinants of plateletpheresis‐associated lymphopenia [PDF]

, 2021
Background Plateletpheresis using a leukocyte reduction system (LRS) traps donor WBCs in the LRS chamber, which may lead to lymphopenia, especially in frequent plateletpheresis donors. It seems plausible that this might cause adverse effects.
Ahrens, Norbert, Brosig, Andreas, Burkhardt, Ralph, Hutchinson, James A., Hähnel, Viola, Offner, Robert, Thuer, Linda   +6 more
core   +1 more source

The contribution of von Willebrand factor-GPIbα interactions to persistent aggregate formation in apheresis platelet concentrates [PDF]

, 2016
BACKGROUND AND OBJECTIVES: Apheresis platelet concentrates sometimes contain persistent aggregates (PA). Because apheresis involves extracorporeal circulation, we hypothesized that interactions between GPIbα and von Willebrand factor (VWF) underlie their
Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Van Aelst, Britt, Vandekerckhove, Philippe   +4 more
core   +2 more sources

Can platelet yield be predicted before the donation in plateletpheresis? A study on the impact of donors’ and procedural parameters on platelet yield [PDF]

Journal of Medical and Life Science
Background: Platelet transfusion plays a critical role in thrombocytopenic patients. Platelet concentrate was prepared by using apheresis technique (SDP), and its efficacy as platelet yield was correlated with donors’ demographic variables.Objectives: To
Purti Saini, Sandeep Matreja, Kushpreet Kaur, Preeti Chakrabarti   +3 more
doaj   +1 more source