Results 81 to 90 of about 545 (124)
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Agranulocytosis Induced by Trimeprazine

New England Journal of Medicine, 1959
PHENOTHIAZINE derivatives have long been known to have serious toxic effects in a small number of susceptible persons.
Philip S Brachman, Brachman Philip S
exaly   +3 more sources

Trimeprazine

2007
Keith Hillier, Richard Jewell
exaly   +2 more sources

Trimeprazine Agranulocytosis

Archives of Dermatology, 1960
Introduction In 1958 a new phenothiazine derivative, trimeprazine, * was introduced as a nonspecific oral agent for the treatment of pruritus. Preliminary studies indicated its usefulness in a wide variety of itching dermatoses which are, according to our present knowledge, unrelated etiologically. The mechanism of action is obscure.
W E, CLENDENNING   +2 more
openaire   +2 more sources

Pharmacokinetics of Trimeprazine in Children

Pharmacology & Toxicology, 1990
The pharmacokinetics of trimeprazine (alimemazine) were studied over 24 hr in six children after a recommended preanaesthetic oral dose of 3 mg · kg‐1. The degree of sedation before anaesthesia was evaluated. Median maximal venous blood drug concentration was 0.357 μmol · 1‐1, 1–2 hr after oral ingestion, half‐life 6.8 hr and AUC0‐∞h 2.758 μmol · 1‐1 ...
S, Sponheim   +3 more
openaire   +2 more sources

Double-Blind Evaluation of Trimeprazine

A.M.A. Archives of Dermatology, 1959
Recently, a phenothiazine derivative, trimeprazine (Temaril * ), was reported on 1 in fairly glowing terms as being valuable in the relief of itching when taken orally. For example, Callaway and Olansky 1 found that 82% of their patients with various skin conditions obtained good or excellent relief of itching while taking the drug.
openaire   +2 more sources

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