Results 111 to 120 of about 12,013 (243)

Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

Animal Models and Experimental Medicine, Volume 8, Issue 1, Page 67-91, January 2025.
A summary of ISP mechanisms in inducing cardiac fibrosis. Abstract Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases. Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium.
Lujain Bader Eddin, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha, Samer N. Goyal, Shreesh Ojha   +4 more
wiley   +1 more source

Trimetazidine effects on intracellular Са2+ ion concentration in HL-60 human promyelocytes

Кардиоваскулярная терапия и профилактика, 2008
Aim. To investigate the effects of an anti-ischemic medication trimetazidine on Са2+ ion metabolism in human leukocyte and monocyte precursors – HL-60 promyelocytes.Material and methods. HL-60 cells were cultivated in vitro. Changes in intracellular free
E. I. Astashkin, M. G. Glezer, S. V. Grachev   +2 more
doaj  

Effects of sustained-release trimetazidine on chronically dysfunctional myocardium of ischemic dilated cardiomyopathy – Six months follow-up result

Indian Heart Journal, 2016
Background: Ischemic cardiomyopathy is a growing burden in third world countries. So far, benefits of trimetazidine in this group of patients have been suggested by clinical trials mainly conducted in Europe.
A. Momen, M. Ali, P.K. Karmakar, M.Z. Ali, A. Haque, M.R. Khan, M.I. Khalil, M.S. Hossain, R.M. Huda, M.N. Goni   +9 more
doaj   +1 more source

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]

, 2019
Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro, Elisabetta Ferraro, Fielding RA, Francesca De Santa, Galván-Peña S, Hard GC, Huang X, Kawanishi N, Laura Vitiello, Munder M, Ménégaut L, Ohtsu A, Tidball JG, Zhang X   +13 more
core   +1 more source

Construction of an Extracellular Matrix–Related Risk Model to Analyze the Correlation Between Glioblastoma and Tumor Immunity

BioMed Research International, Volume 2025, Issue 1, 2025.
Background: Abnormalities in the extracellular matrix (ECM) have been shown to play a crucial role in promoting the formation, progression, and metastasis of glioblastoma multiforme (GBM). Therefore, our study is aimed at constructing a prognostic model based on ECM‐related factors, to predict the prognosis of patients with GBM.
Jian Li, Hong Pan, Yangyang Wang, Haixin Chen, Zhaopeng Song, Zheng Wang, Jinxing Li, Abhishek Tyagi   +7 more
wiley   +1 more source

Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy [PDF]

, 2015
Objectives: The aim of this study was to determine whether short-term treatment with perhexiline improves cardiac energetics, left ventricular function, and symptoms of heart failure by altering cardiac substrate utilization.
Abozguia, Balgi, Beadle, Birks, Bottomley, Cavassila, Cole, Conway, Conway, Dedkova, Fragasso, Gao, Gatto, Horowitz, Hugel, Hughes, Kennedy, Lee, Neubauer, Rich, Sanbe, Schiller, Shivu, Stewart, Thackray, Unger   +25 more
core   +1 more source

Acute Tubulointerstitial Nephritis (ATIN) in Patient With Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Case Report

Case Reports in Nephrology, Volume 2025, Issue 1, 2025.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by diffuse renal cysts that secrete cytokines, which induce interstitial inflammation and fibrosis. Meanwhile, acute tubulointerstitial nephritis (ATIN) is characterized by inflammatory infiltrates in the interstitium, where kidney biopsy remains the mainstay for ...
Mohammad Alsultan, Marwa Kliea, Alaa Aldin Zedan, Qussai Hassan, Poorani Gurumallesh   +4 more
wiley   +1 more source

Trimetazidine in coronary heart disease patients: mechanism of action and controlled trials’ results

Кардиоваскулярная терапия и профилактика, 2005
Metabolic cardioprotection is an important part of treating patients with coronary heart disease (CHD). The most widely used drug in this group is trimetazidine.
L. V. Kremneva, O. V. Abaturova, S. V. Shalaev   +2 more
doaj  

Changes in expression and activity of the secretory pathway Ca2+ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells cultured at different glucose concentrations [PDF]

, 2009
Diabetes mellitus-related vascular disease is often associated with both a dysregulation of Ca\(^{2+}\) homoeostasis and enhanced secretory activity in VSMCs (vascular smooth muscle cells).
Al-Bader, Aronson, Barbagallo, Byron, Curtis, Di Napoli, Dode, Dode, Fleischhacker, Francesco Michelangeli, Han, Hiromura, Kawada, Levy, Li, Mazzone, Missiaen, Mitchell, Ogunbayo, Owens, Pei Lai, Reinhardt, Shahbazi, Smogorzewski, Stalker, Teshima, Thyberg, Thyberg, Tong, Vanoevelen, Varadi, Wootton, Wootton, Wright, Yousif   +34 more
core   +6 more sources

Effect of Trimetazidine on Left Ventricular Function in Heart Failure Secondary to Ischemic Heart Disease

Gomal Journal of Medical Sciences, 2010
Background: Ischemic heart disease is the leading cause of heart failure. This study was conducted to see the effect of Trimetazidine on left ventricular function in heart failure secondary to ischemic heart disease.
Shimal Khan, Amjad Abrar, Abdul Rehman Abid, Tehmina Jan, Habibullah Khan   +4 more
doaj