Results 91 to 100 of about 8,387 (243)

Trimetazidine improves angiogenesis and tissue perfusion in ischemic rat skeletal muscle

Frontiers in Pharmacology
Introduction: Peripheral artery disease (PAD) is an increasingly common disease, causing significant complications for patients. Trimetazidine (TMZ) not only improves clinical symptoms in PAD patients but also facilitates angiogenesis in ischemic hind ...
Yongting Pan, Li Mai, Wen-Kai He, Xuqi Yang, En-Ting Wu, Jiayuan Zhao, Bailiang Liu, Ming-Yan Li   +7 more
semanticscholar   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1271-1287, March 2026.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Comparison of antianginal and antiischemic efficacy of cytoprotectors, nitrates, and beta-blockers during monotherapy and combined therapy in patients with effort angina and silent myocardial ischemia episodes

Российский кардиологический журнал, 2004
In 57 patients with stable effort angina, functional class II-III, and episodes of silent myocardial ischemia, antianginal and antiischemic efficacy of trimetazidine, isosorbide-5-mononitrate, and nadolol (monotherapy and combined therapy) was compared ...
S. N. Vaslyaeva, O. V. Zygankova, I. G. Gordeev, N. A. Volov   +3 more
doaj  

MEMBRANE-SАVING ACTION OF TRIMETAZIDINE IN SUBJECTS WITH ACUTE MYOCARDIAL INFARCTION

Российский кардиологический журнал, 2014
The article concerns the assessment of functional condition of cell membranes in a variety of pathological conditions, influence of various physical and chemical factors and pharmacological drugs. Aim.
S. V. Vasilyev, E. Yu. Maychuk, V. Yu. Vasilyev   +2 more
doaj   +1 more source

Meta-analysis of trimetazidine treatment for cardiomyopathy [PDF]

Bioscience Reports, 2018
To explore the effect of trimetazidine (TMZ) in cardiomyopathy treatment. Literatures, related with TMZ treatment for cardiomyopathy, were retrieved between 1990 and February 2018 in the Pubmed, Embase, and Cochrane Library systems. Cardiopulmonary exercise testing [resting heart rate (RHR), peak heart rate (PHR), peak systolic blood pressure (PSBP ...
Fan, Qian, Niu, Zhaozhuo, Ma, Liqing
openaire   +2 more sources

Influence of trimetazidine on myocardial injury in mice with diabetic cardiomyopathy.

Journal of diabetes and its complications
INTRODUCTION The prevalence of diabetes mellitus is increasing year by year globally, and diabetic cardiomyopathy (DCM), as the most common complication of type 2 diabetes mellitus, seriously affects the prognosis of patients.
Dongmin Zhao, Jing Ma, Yu-Man Sun, Wei Huang, Jinyang Fan, Mingzhe Ye, Bo Hu, Xinyi Sun   +7 more
semanticscholar   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Effects of trimetazidine on submaximal exercise test in patients with acute myocardial infarction

, 2003
Background: It was demonstrated that the novel metabolic agent, trimetazidine, could lessen the incidence and severity of angina, whether used in monotherapy or combination.
GUNES, Abdulbaki, GULER, N, Tuncer, Mustafa, ERYONUCU, B, OZBEK, H, GUNTEKIN, U   +5 more
core   +1 more source

Efficacy and safety of yangxinshi versus trimetazidine on exercise tolerance in patients with coronary heart disease after percutaneous coronary intervention: Multicenter, double-blind clinical trial.

Phytomedicine
BACKGROUND Optimizing medication to improve exercise tolerance in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI) is limited. Yangxinshi tablets, an herbal-based oral medicine, relieve symptoms of angina might be
Yang Li, Yi Li, Zhi-Jie Zhang, Jian Zhang, Hong Chen, Haichu Yu, Xiao-Ping Meng, Hai-Tao Yuan, L. Shao, Yan Lu, Bin Liu, Jiayao Xu, Yi Zhang, Jing Li, Ya-Ling Han   +14 more
semanticscholar   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source