Results 81 to 90 of about 8,387 (243)

Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study

Cardiovascular Diabetology, 2003
Background Patients with diabetic cardiomyopathy have an impaired myocardial glucose handling and distal distribution of coronary atherosclerosis. Trimetazidine, an anti-ischemic metabolic agent, improves myocardial glucose utilization though inhibition ...
Mercuro Giuseppe, Sposato Barbara, Vitale Cristiana, Rosano Giuseppe MC, Fini Massimo   +4 more
doaj   +1 more source

Biochemical Aspects That Lead to Abusive Use of Trimetazidine in Performance Athletes: A Mini-Review

International Journal of Molecular Sciences
Trimetazidine (TMZ), used for treating stable angina pectoris, has garnered attention in the realm of sports due to its potential performance-enhancing properties, and the World Anti-Doping Agency (WADA) has classified TMZ on the S4 list of prohibited ...
Amalia Pușcaș, Ruxandra Ștefănescu, C. Vari, Bianca-Eugenia Ősz, Cristina Filip, Jana Karlina Bitzan, Mădălina-Georgiana Buț, Amelia Tero-Vescan   +7 more
semanticscholar   +1 more source

Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling

BMJ Open Diabetes Research & Care, 2022
Introduction Insulin resistance (IR) plays a key role in the pathogenesis and clinical course of patients with multiple metabolic diseases and diabetes.
Wen-Liang Zhang, Y. Dun, Baiyang You, Ling Qiu, J. W. Ripley-Gonzalez, Jing Cheng, Siqian Fu, Cui Li, Sui-Xin Liu   +8 more
semanticscholar   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Practical Metabolic Approaches in Chronic Coronary Syndrome and Beyond: Clinical Role of Trimetazidine

Indian Journal of Clinical Cardiology
The burden of ischemic heart disease has increased globally. In India, the estimated prevalence of angina was around 3.7%. Chronic coronary syndrome, angina pectoris, occurs from an imbalance between oxygen supply and demand in the myocardium.
Ritu Bhatia, Vansh Dhawan, Ansh Bhatia
doaj   +1 more source

Trimetazidine Improves Mitochondrial Dysfunction in SOD1G93A Cellular Models of Amyotrophic Lateral Sclerosis through Autophagy Activation

International Journal of Molecular Sciences
Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease, characterized by motor neuron loss and muscle waste. A well-established pathogenic hallmark of ALS is mitochondrial failure, leading to bioenergetic deficits. So far,
I. Salvatori, Valentina Nesci, A. Spalloni, Veronica Marabitti, M. Muzzi, Henri Zenuni, Silvia Scaricamazza, M. Rosina, Gianmarco Fenili, Mariangela Goglia, Laura Boffa, Roberto Massa, Sandra Moreno, N. Mercuri, F. Nazio, P. Longone, A. Ferri, C. Valle   +17 more
semanticscholar   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Evaluation of Endoplasmic Reticulum Stress in an Experimental Intestinal Ischemia–Reperfusion Model in Rats: The Role of Ozone Therapy and Trimetazidine

Biomolecules
Aim: The objective of the study was to assess the impact of ozone (O3) and trimetazidine on the intestines following ischemia–reperfusion (I/R) injury through the investigation of endoplasmic reticulum stress.
Gökhan Demiral, T. Mercantepe, Gurkan Altuntas, A. Pergel, Süleyman Kalcan, A. Ozdemir, L. Tumkaya, Sibel Mataracı Karakaş, Aykut Ozturk, A. Yılmaz   +9 more
semanticscholar   +1 more source

Assessment of Quality of Care Provided for Patients Receiving Post‐Myocardial Infarction Care at Selected Cardiac Clinics in Sulaymaniyah: Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background According to global projections, by the year 2050, ischemic heart disease will remain the leading cause of cardiovascular deaths with hypertension as a leading modifiable risk factor for mortality. Improving quality care for patients with acute myocardial infarction (MI) is associated with improved outcomes. Aims There is inadequate
Banaz Sadiq Elias, Yara Sarwar Hamid, Mende Mensa Sorato   +2 more
wiley   +1 more source

Effects of trimetazidine on myocardial preconditioning in anesthetized rats

, 2004
Trimetazidine is a widely used anti-ischemic agent, but its effect on myocardial preconditioning in anesthetized animals has not been investigated.
Tarakcioglu, M, Demiryurek, AT, Demiryurek, S, Kara, AF, Celik, A   +4 more
core   +1 more source