The effect of topical nitroglycerin on symmetrical peripheral gangrene in a pediatric patient. [PDF]
Symmetrical peripheral gangrene is a rare condition associated with significant morbidity and mortality. The use of topical nitroglycerin may have a role in improving patient outcomes and opens a new area for future research regarding the use of topical nitroglycerin in SPG.
Alfraij A, Elseadawy M, Alghounaim M.
europepmc +2 more sources
Central α<sub>2</sub>-adrenergic mechanisms regulate human sympathetic neuronal discharge strategies. [PDF]
Abstract figure legend The present study investigated the impact of central α2‐adrenergic mechanisms on sympathetic action potential (AP) discharge, recruitment and latency strategies. We used the microneurographic technique to record muscle sympathetic nerve activity and a continuous wavelet transform to investigate postganglionic sympathetic AP ...
Klassen SA +10 more
europepmc +2 more sources
Fructose-induced salt-sensitive blood pressure differentially affects sympathetically mediated aortic stiffness in male and female Sprague-Dawley rats. [PDF]
In male rats, fructose‐high salt diet results in elevated blood pressure and increased aortic stiffness. Despite earlier evidence of preserved left ventricular ejection fraction (LVEF), male rats on the fructose high salt diet display a deficit in myocardial function measured as reduced global longitudinal strain.
Komnenov D, Rossi NF.
europepmc +2 more sources
Relationship between Alzheimer dementia and QT interval: A meta-analysis. [PDF]
The increased QT in dementia and the direct correlation between QT interval and the severity of dementia focuses attention on understanding the determinants of aging‐associated QT prolongation which appear to be important for understanding aging‐induced dementia and mortality.
Rabkin SW.
europepmc +2 more sources
Carotid sinus baroafferent signals contribute to cerebral blood flow regulation during acute hypotension in young males: A randomized crossover study. [PDF]
Abstract Cerebral autoregulation is an important factor in prevention of cerebral ischemic events. We tested a traditional but unproven hypothesis that carotid sinus baroafferent signals contribute to dynamic cerebral autoregulation. Middle cerebral artery mean blood velocity (MCA Vmean) responses to thigh‐cuff deflation‐induced acute hypotension were ...
Ishii K, Izaki T, Asahara R, Komine H.
europepmc +2 more sources
Remote ischaemic preconditioning – translating cardiovascular benefits to humans
Abstract figure legend Explanation of the effects of single bout as opposed to repeated bouts of remote ischaemic preconditioning. Abstract Remote ischaemic preconditioning (RIPC), induced by intermittent periods of limb ischaemia and reperfusion, confers cardiac and vascular protection from subsequent ischaemia–reperfusion (IR) injury.
James A. Lang, Jahyun Kim
wiley +1 more source
Exercise-induced potentiation of the acute hypoxic ventilatory response: Neural mechanisms and implications for cerebral blood flow. [PDF]
Abstract A given dose of hypoxia causes a greater increase in pulmonary ventilation during physical exercise than during rest, representing an exercise‐induced potentiation of the acute hypoxic ventilatory response (HVR). This phenomenon occurs independently from hypoxic blood entering the contracting skeletal muscle circulation or metabolic byproducts
Oliveira DM +3 more
europepmc +2 more sources
Ganglionic blocker, chlorisondamine, can be used to assess the neurogenic contribution to BP in mice, but may not be appropriate to specifically estimate the vasomotor sympathetic tone. Abstract Chlorisondamine (CSD) has been used to assess the neurogenic contribution to blood pressure (BP) and vasomotor sympathetic tone in animal models. It is assumed
Lucas AC. Souza +4 more
wiley +1 more source
A framework for the interpretation of heart rate variability applied to transcutaneous auricular vagus nerve stimulation and osteopathic manipulation. [PDF]
Abstract Reports on autonomic responses to transcutaneous auricular vagus nerve stimulation (taVNS) and osteopathic manipulative techniques have been equivocal, partly due to inconsistent interpretation of heart rate variability (HRV). We developed a mechanistic framework for the interpretation of HRV based on a model of sinus node automaticity that ...
Kania A, Roufail J, Prokop J, Stauss HM.
europepmc +2 more sources
Steady blood pressure within normal limits during surgery is one of the markers of the ideal and skillful anesthesia. Yet, reduced blood pressure is advantageous in some settings because it can contribute to a reduction in overall blood loss and improve the surgical field conditions. Controlled hypotension during anesthesia or hypotensive anesthesia is
Michal Barak +3 more
wiley +1 more source

