Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence [PDF]
EBioMedicine, 2018 Background: Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD.
Amy L Conrad +2 more
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Trinucleotide Repeats: A structural perspective [PDF]
Frontiers in Neurology, 2013 Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function ...
Bruno eAlmeida +3 more
doaj +5 more sources
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Cell Reports, 2018 Summary: Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington’s disease. Because expansions trigger the disease, contracting repeat length could be
Valentine Mosbach +2 more
exaly +4 more sources
Chronic Exposure to Cadmium and Antioxidants Does Not Affect the Dynamics of Expanded CAG•CTG Trinucleotide Repeats in a Mouse Cell Culture System of Unstable DNA [PDF]
Frontiers in Cellular Neuroscience, 2021 More than 30 human disorders are caused by the expansion of simple sequence DNA repeats, among which triplet repeats remain the most frequent. Most trinucleotide repeat expansion disorders affect primarily the nervous system, through mechanisms of ...
Mário Gomes-Pereira, Darren G. Monckton
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Construction of DNA/RNA Triplex Helices Based on GAA/TTC Trinucleotide Repeats [PDF]
Bio-Protocol, 2021 Atypical DNA and RNA secondary structures play a crucial role in simple sequence repeat (SSR) diseases, which are associated with a class of neurological and neuromuscular disorders known as “anticipation diseases,” where the age of disease onset ...
Jiahui Zhang +4 more
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Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats [PDF]
Nature Communications, 2021 DNA three-way junctions are branched structures formed during replication, repair, and recombination, and are involved in models of repeat expansion. Here the authors use single-molecule Förster resonance energy transfer to reveal the dynamics of DNA ...
Tianyu Hu +2 more
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Variation within the Huntington's disease gene influences normal brain structure. [PDF]
PLoS ONE, 2012 Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we
Mark Mühlau +9 more
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Trinucleotide repeat disorders
, 2018 Trinucleotide repeat disorders comprise a variable group of inherited neurodegenerative diseases, with a large range in prevalence figures. There is a broad range in clinical presentations, but many of these diseases lead to some form of ataxia or other movement disorders, which are frequently combined with cognitive or psychiatric disturbances.
den Dunnen, Wilfred; id_orcid
openaire +4 more sources
Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats. [PDF]
Genes (Basel), 2022 The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible for developing neurodegenerative
Belkozhayev A +8 more
europepmc +2 more sources
Signatures of selection in mammalian clock genes with coding trinucleotide repeats: Implications for studying the genomics of high‐pace adaptation [PDF]
Ecology and Evolution, 2017 Climate change is predicted to affect the reproductive ecology of wildlife; however, we have yet to understand if and how species can adapt to the rapid pace of change.
Melanie B. Prentice +8 more
doaj +2 more sources