Studies on Copper and Aβ-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence [PDF]
Journal of Alzheimer's Disease Reports, 2017 DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc.
M. Govindaraju +5 more
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CGG, CAG, and GAA: Genome-wide comparison of the disease linked trinucleotide short tandem repeats [PDF]
BMC GenomicsShort tandem repeats (STRs) are tracts of 1–6 bp DNA motifs repeated in a head-to-tail fashion, collectively accounting for approximately 3% of the human genome.
Dale J. Annear +2 more
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Small interfering RNA s based on huntingtin trinucleotide repeats are highly toxic to cancer cells [PDF]
EMBO Reports, 2018 Andrea E Murmann +2 more
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Stem Cell Research, 2021 IPSC line RCPCMi004-8 was generated from skin fibroblasts collected from a male patient with spinocerebellar ataxia 17. The patient has expanded trinucleotide CAG repeats in the TBP (TATA-binding protein) gene on chromosome 6q27.
L.D. Shuvalova +9 more
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Development of novel macrocyclic small molecules that target CTG trinucleotide repeats [PDF]
Bioorganic and Medicinal Chemistry, 2019 Julio F Serrano +2 more
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Computational and Structural Biotechnology Journal, 2021 Pathogenic DNA secondary structures have been identified as a common and causative factor for expansion in trinucleotide, hexanucleotide, and other simple sequence repeats.
Feng Pan +6 more
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Validation of methylation-specific polymerase chain reaction method and evaluation of FMR1 gene pre-mutations in premature ovarian insufficiency [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Fragile X-associated premature ovarian insufficiency is clinically defined as a type of early ovarian failure with irregular menstrual cycles, increased follicle-stimulating hormone, premature menopause, and infertility.
Fatemeh Afkhami +3 more
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Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast. [PDF]
PLoS ONE, 2014 Trinucleotide repeat expansions are responsible for more than two dozens severe neurological disorders in humans. A double-strand break between two short CAG/CTG trinucleotide repeats was formerly shown to induce a high frequency of repeat contractions ...
Guy-Franck Richard +5 more
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CTG trinucleotide repeat "big jumps": large expansions, small mice. [PDF]
PLoS Genetics, 2007 Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1.
Mário Gomes-Pereira +6 more
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Brain Sciences, 2023 Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder that is caused by the abnormal expansion of non-coding trinucleotide GGC repeats in NOTCH2NLC.
Yusran Ady Fitrah +24 more
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