Results 141 to 150 of about 585,191 (278)

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation. [PDF]

Nucleic Acids Res, 2021
Konieczny P, Mukherjee S, Stepniak-Konieczna E, Taylor K, Niewiadomska D, Piasecka A, Walczak A, Baud A, Dohno C, Nakatani K, Sobczak K.   +10 more
europepmc   +1 more source

A Family of Developmentally Excised DNA Elements in \u3cem\u3eTetrahymena\u3c/em\u3e is under Selective Pressure to Maintain an Open Reading Frame Encoding an Integrase-Like Protein [PDF]

, 2000
Tlr1 is a member of a family of ~20-30 DNA elements that undergo developmentally regulated excision during formation of the macronucleus in the ciliated protozoan Tetrahymena.
Gershan, Jill A., Karrer, Kathleen M.
core   +1 more source

ZIP-seq: genome-wide mapping of trinucleotide repeats at single-base resolution [PDF]

, 2013
Xingxing Xu, Yonghui Tao, Xing Fu, Tao Yu, Yuanyuan Li, Kan Chen, Xiaoyan Ding, Kangcheng Ruan, Naihe Jing, Ronggui Hu   +9 more
openalex   +1 more source

Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus [PDF]

, 2002
BACKGROUND: Ten neurodegenerative disorders characterized by spinocerebellar ataxia (SCA) are known to be caused by trinucleotide repeat (TNR) expansions.
Alonso, I, Barbot, C, Barros, J, Coelho, J, Ferreirinha, F, Ferro, A, Guimarães, L, Januário, C, Mendonça, P, Miranda, C, Moreira, MC, Pinto-Basto, J, Poirier, J, Silveira, I, Tuna, A, Vale, J   +15 more
core  

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2. [PDF]

Front Genet, 2021
Garribba L, Vogel I, Lerdrup M, Gonçalves Dinis MM, Ren L, Liu Y.   +5 more
europepmc   +1 more source

Huntington disease: DNA analysis in brazilian population

Arquivos de Neuro-Psiquiatria, 2000
Huntington disease (HD) is associated with expansions of a CAG trinucleotide repeat in the HD gene. Accurate measurement of a specific CAG repeat sequence in the HD gene in 92 Brazilian controls without HD, 44 Brazilian subjects with clinical findings ...
RASKIN SALMO, ALLAN NASSER, TEIVE HÉLIO A.G., CARDOSO FRANCISCO, HADDAD MÔNICA SANTORO, LEVI GILBERTO, BOY RAQUEL, LERENA JR JUAN, SOTOMAIOR VANESSA SANTOS, JANZEN-DÜCK MÔNICA, JARDIM LAURA BANNACH, FELLANDER FLÁVIO R., ANDRADE LUIZ AUGUSTO FRANCO   +12 more
doaj  

Stick-slip unfolding favors self-association of expanded HTT mRNA

Nature Communications
In Huntington’s Disease (HD) and related disorders, expansion of CAG trinucleotide repeats produces a toxic gain of function in affected neurons.
Brett M. O’Brien, Roumita Moulick, Gabriel Jiménez-Avalos, Nandakumar Rajasekaran, Christian M. Kaiser, Sarah A. Woodson   +5 more
doaj   +1 more source

Expandable DNA Repeat and Human Hereditary Disorders [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia.
Shahin Ramazi, Ali Fasihi, Maryam Godarziyan, Morteza Hashemzadeh-Chaleshtori   +3 more
doaj  

Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation.

Angewandte Chemie, 2017
W. Tseng, Chung-ke Chang, Pei-Ching Wu, N. Hu, Gene-Hsiang Lee, C. Tzeng, S. Neidle, M. Hou   +7 more
semanticscholar   +1 more source

A rapid method for sequencing trinucleotide repeats [PDF]

, 1993
Russell L. Margolis, Shi-Hua Li, Christopher A. Ross   +2 more
openalex   +1 more source