Results 131 to 140 of about 17,057 (211)

Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in mice. [PDF]

Nat Genet
Matuszek Z, Arbab M, Kesavan M, Hsu A, Roy JCL, Zhao J, Yu T, Weisburd B, Newby GA, Doherty NJ, Wu M, Shibata S, Cristian A, Tao YA, Fearnley LG, Bahlo M, Rehm HL, Xie J, Gao G, Mouro Pinto R, Liu DR.   +20 more
europepmc   +1 more source

Comparative Study of the Bending Free Energies of C- and G-Based DNA: A-, B-, and Z-DNA and Associated Mismatched Trinucleotide Repeats. [PDF]

J Chem Inf Model
Fakharzadeh A, Moradi M, Sagui C, Roland C.   +3 more
europepmc   +1 more source

The Influence of Trinucleotide Repeats in the Androgen Receptor Gene and Testosterone Level on Circulating Proteins in Male Participants: Proteomics Analysis Using the UK Biobank Data. [PDF]

JMA J
Sasako T, Ilboudo Y, Chen Y, Liang KYH, Yoshiji S, Richards JB.   +5 more
europepmc   +1 more source

Trinucleotide repeats and neuropsychiatric phenotypes [Elektronisk resurs]

, 2001
Genetic studies of affective disorders have yielded several chromosomal regions suggestive for linkage. Linkage analysis was performed in five families with unipolar affective disorder, collected from northern Sweden.
Yuan, Q-P,
core  

Generation of Rhesus Macaque Embryos with Expanded CAG Trinucleotide Repeats in the Huntingtin Gene. [PDF]

Cells
Ryu J, Statz JP, Chan W, Oyama K, Custer M, Wienisch M, Chen R, Hanna CB, Hennebold JD.   +8 more
europepmc   +1 more source

Genomic studies of expanded trinucleotide repeats : focus on neuropsychiatric disorders

, 1998
In a number of neurological and neuropsychiatric disorders, a worsening of the disease phenotype from one generation to the next has been linked to expanded trinucleotide repeat sequences that increase in size upon transmission.
Kerstin Lindblad (19493515)
core  

Quantitative investigations of FXN transcription and epigenetic modifications, including histone acetylation and methylation, in FRDA human and mouse tissues

, 2009
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive gait and, limb ataxia, cardiomayopathy ...
Trabzuni, Daniah M
core  

Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia. [PDF]

Neurol Genet, 2018
Tojima M, Murakami G, Hikawa R, Yamakado H, Yamashita H, Takahashi R, Matsui M.   +6 more
europepmc   +1 more source

Amplification-free long-read sequencing of TCF4 expanded trinucleotide repeats in Fuchs Endothelial Corneal Dystrophy. [PDF]

PLoS One, 2019
Wieben ED, Aleff RA, Basu S, Sarangi V, Bowman B, McLaughlin IJ, Mills JR, Butz ML, Highsmith EW, Ida CM, Ekholm JM, Baratz KH, Fautsch MP.   +12 more
europepmc   +1 more source

p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich's Ataxia. [PDF]

Molecules, 2019
Helma R, Bažantová P, Petr M, Adámik M, Renčiuk D, Tichý V, Pastuchová A, Soldánová Z, Pečinka P, Bowater RP, Fojta M, Brázdová M.   +11 more
europepmc   +1 more source