Results 111 to 120 of about 17,057 (211)

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation. [PDF]

Nucleic Acids Res, 2021
Konieczny P, Mukherjee S, Stepniak-Konieczna E, Taylor K, Niewiadomska D, Piasecka A, Walczak A, Baud A, Dohno C, Nakatani K, Sobczak K.   +10 more
europepmc   +1 more source

Expanded trinucleotide CAG repeats in families with bipolar affective disorder

, 1997
Clinical anticipation has been reported in bipolar affective disorder (BPAD). The hypothesis that expanded trinucleotide repeats are related to anticipation and transmission pattern in families with bipolar affective disorder is tested in this study ...
Mahieu, Brigitte, Lindbald, Kerstin, Per Olof Nylander, Olivier Lipp, Lipp, Olivier, Zander, Cecilia, An De Bruyn, Zander, C., Engström, Christer, Adolfsson, Rolf, Schalling, Martin, Julien Mendlewicz, Rolf Adolfsson, Mendlewicz, Julien, Schalling, M., De Bruyne, Anne, Adolfsson, C.M.R., Daniel Souery, Christer Engström, Mendlewicz, J., Nylander, P.O., Cecilia Zander, Kerstin Lindbald, Nylander, Peter O, Souery, D., de Bruyn, A., Lindblad, K., Lipp, O., Brigitte Mahieu, Martin Schalling, Souery, Daniel, Van Broeckhoven, Christine, Mahieu, Boris, Christine Van Broeckhoven   +33 more
core   +1 more source

Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats. [PDF]

Nucleic Acids Res, 2022
Fakharzadeh A, Zhang J, Roland C, Sagui C.   +3 more
europepmc   +1 more source

Instability at dinucleotide and trinucleotide repeats in breast cancer

, 2000
We analyzed 7 mono-, 6 di- and 2 trinucleotide repeat loci in a well characterized series of 69 breast cancer cases, treated in the period 1985-1986 and followed for 12 years.
M. Falchetti, M. Paglierani, C. Noviello, V. Vezzosi, C. D'Amico, S. Bianchi, OTTINI, LAURA, A. Russo, C. Saieva, A. M. Corsi, G. Masala, D. Palli, R. Mariani Costantini   +12 more
core  

Trinucleotide Repeats Number in SCA2, SCA3, and SCA17 in Early-Onset Parkinson’s Disease [PDF]

, 2008
BACKGROUND: Abnormal expansion of trinucleotide repeats in genes causing spinocerebellar ataxias such as SCA2, SCA3, SCA8, or SCA17 was reported in sporadic or familial Parkinson's disease. Genetic factors play an important role especially in early-onset
강석윤, 신혜원, 손영호, 이명식, 류철형   +4 more
core  

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2. [PDF]

Front Genet, 2021
Garribba L, Vogel I, Lerdrup M, Gonçalves Dinis MM, Ren L, Liu Y.   +5 more
europepmc   +1 more source

Huntington disease: DNA analysis in brazilian population

Arquivos de Neuro-Psiquiatria, 2000
Huntington disease (HD) is associated with expansions of a CAG trinucleotide repeat in the HD gene. Accurate measurement of a specific CAG repeat sequence in the HD gene in 92 Brazilian controls without HD, 44 Brazilian subjects with clinical findings ...
RASKIN SALMO, ALLAN NASSER, TEIVE HÉLIO A.G., CARDOSO FRANCISCO, HADDAD MÔNICA SANTORO, LEVI GILBERTO, BOY RAQUEL, LERENA JR JUAN, SOTOMAIOR VANESSA SANTOS, JANZEN-DÜCK MÔNICA, JARDIM LAURA BANNACH, FELLANDER FLÁVIO R., ANDRADE LUIZ AUGUSTO FRANCO   +12 more
doaj  

Stick-slip unfolding favors self-association of expanded HTT mRNA

Nature Communications
In Huntington’s Disease (HD) and related disorders, expansion of CAG trinucleotide repeats produces a toxic gain of function in affected neurons.
Brett M. O’Brien, Roumita Moulick, Gabriel Jiménez-Avalos, Nandakumar Rajasekaran, Christian M. Kaiser, Sarah A. Woodson   +5 more
doaj   +1 more source

Bias in the genomic distribution of CAG and CTG trinucleotide repeats

, 1997
We investigated the hypothesis that the trinucleotide repeat CAG is disproportionately located in exons in genomic DNA by analyzing unbiased genomic sequences with the Gene Recognition and Analysis Internet Link program (http@avalon.epm.ornl.gov/). Forty
Guy, C, O'Donovan, Michael Conlon
core   +1 more source

Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder

, 1997
OBJECTIVE: The purpose of this study was to identify the specific expanded CAG/CTG trinucleotide repeat associated with bipolar disorder. METHOD: The study employed an efficient multistage approach for using a genomic CAG/CTG screening set. RESULTS:
Daniels, J. K., Claffey, E., Craddock, Nicholas, Bowen, Timothy, McKeon, P., O'Donovan, Michael Conlon, Guy, Carol, McGuffin, P., Speight, G., Owen, Michael John, Mynett-Johnson, L.   +10 more
core