Results 91 to 100 of about 17,057 (211)
STABILITY OF GAA/TTC AND CTG/CAG TRINUCLEOTIDE REPEATS DURING BREAK-INDUCED REPLICATION IN YEAST
, 2012 poster abstractSeveral human neurodegenerative disorders are caused by the expansion of trinucleotide repeats within or near the region of genes. To study the sta-bility of trinucleotide repeats in eukaryotic cells, we insert different number of GAA and ...
Chen, Yu-Hsiang, Malkova, Anna
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Clinical and genetic study of one DRPLA case
Chinese Journal of Contemporary Neurology and Neurosurgery, 2010 Objective To investigate the clinical and genetic features of dentatorubral ⁃ pallidoluysian atrophy (DRPLA). Methods The trinucleotide repeats of spinocerebellar ataxia (SCA) disease genes were detected by polymerase chain reaction (PCR) initially in ...
Ying HAO +6 more
doaj
BioTechniques, 2018 Numerous human diseases are associated with abnormal expansion of unstable trinucleotide repeats (TNRs). TNR instability mechanisms are complex, and remain only partially understood.
Elodie Dandelot, Geneviève Gourdon
doaj +1 more source
BiomoleculesDynamic mutations in some human genes containing trinucleotide repeats are associated with severe neurodegenerative and neuromuscular disorders—known as Trinucleotide (or Triplet) Repeat Expansion Diseases (TREDs)—which arise when the repeat number of ...
Feng Pan +4 more
doaj +1 more source
A trinucleotide repeat biosensor [PDF]
Nature Methods, 2005 A small-molecule ligand that binds to a (CAG)n hairpin repeat is the basis of a biosensor to detect repeat length, which may help diagnose trinucleotide repeat disease severity.
openaire +1 more source
Trinucleotide repeats in DNA replication and gene expression.
, 2001 Trinucleotide repeats in DNA replication and gene ...
Gordana. Raca (7978361)
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Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats
, 2010 R-loops have been described at immunoglobulin class switch sequences, prokaryotic and mitochondrial replication origins, and disease-associated (CAG)n and (GAA)n trinucleotide repeats.
Nichol Edamura, Kerrie +16 more
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Genetic analysis of SCA8 trinucleotide repeats in Parkinson's disease.
, 2013 Trinucleotide repeats have attracted special interest due to their involvement in human neurodegenerative disorders known as the triplet repeat expansion diseases, such as the Spinocerebellar ataxia (SCA).
Lin, Cynthia XinTian.
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Reduced-penetrance Huntington's disease-causing alleles with 39 CAG trinucleotide repeats could be a genetic factor of amyotrophic lateral sclerosis. [PDF]
J Chin Med Assoc, 2023 Jih KY, Lai KL, Lin KP, Liao YC, Lee YC.
europepmc +1 more source
Replication and expansion of trinucleotide repeats in yeast
, 2003 The mechanisms of trinucleotide repeat expansions, underlying more than a dozen hereditary neurological disorders, are yet to be understood. Here we looked at the replication of (CGG)n (CCG)n and (CAG)n (CTG)n repeats and their propensity to expand in ...
Maria M. Krasilnikova +4 more
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