Trinucleotide Repeats: A structural perspective [PDF]
Frontiers in Neurology, 2013 Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function ...
Bruno eAlmeida +3 more
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Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats [PDF]
Nature Communications, 2021 DNA three-way junctions are branched structures formed during replication, repair, and recombination, and are involved in models of repeat expansion. Here the authors use single-molecule Förster resonance energy transfer to reveal the dynamics of DNA ...
Tianyu Hu +2 more
doaj +3 more sources
Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence [PDF]
EBioMedicine, 2018 Background: Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD.
Jessica K. Lee +6 more
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Chronic Exposure to Cadmium and Antioxidants Does Not Affect the Dynamics of Expanded CAG•CTG Trinucleotide Repeats in a Mouse Cell Culture System of Unstable DNA [PDF]
Frontiers in Cellular Neuroscience, 2021 More than 30 human disorders are caused by the expansion of simple sequence DNA repeats, among which triplet repeats remain the most frequent. Most trinucleotide repeat expansion disorders affect primarily the nervous system, through mechanisms of ...
Mário Gomes-Pereira, Darren G. Monckton
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Epigenetics and triplet repeat neurological diseases [PDF]
Frontiers in Neurology, 2015 The term ‘junk DNA’ has been reconsidered following the delineation of the functional significance of repetitive DNA regions. Typically associated with centromeres and telomeres, DNA repeats are found in nearly all organisms throughout their genomes ...
Sathiji eNageshwaran +1 more
doaj +4 more sources
Construction of DNA/RNA Triplex Helices Based on GAA/TTC Trinucleotide Repeats [PDF]
Bio-Protocol, 2021 Atypical DNA and RNA secondary structures play a crucial role in simple sequence repeat (SSR) diseases, which are associated with a class of neurological and neuromuscular disorders known as “anticipation diseases,” where the age of disease onset ...
Jiahui Zhang +4 more
doaj +2 more sources
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Cell Reports, 2018 Summary: Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington’s disease. Because expansions trigger the disease, contracting repeat length could be
Valentine Mosbach +4 more
doaj +2 more sources
p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich's Ataxia. [PDF]
Molecules, 2019 Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich’s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults.
Helma R +11 more
europepmc +3 more sources
Comparative (computational) analysis of the DNA methylation status of trinucleotide repeat expansion diseases [PDF]
, 2013 Copyright © 2013 Mohammadmersad Ghorbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is ...
Ghorbani, M +3 more
core +6 more sources
Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats. [PDF]
Nucleic Acids Res, 2022 Fakharzadeh A +3 more
europepmc +3 more sources