Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Isolation of oligomycin-sensitive adenosine triphosphatase from beef heart mitochondria and analysis of its fine structure [PDF]
, 1967 1. An oligomycin -sensitive ATPase was isolated and partially purified from beef heart mitochondria. The specific activity of ATPase sensitive to oligomycin of the fraction was five to eight times that of aged mitochondrial or of DNP-induced ...
Hayashi, Hideo +4 more
core +1 more source
Complete genome sequence and taxonomic position of anguillid herpesvirus 1 [PDF]
, 2010 Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp
Abma-Henkens, M.H.C. +8 more
core +6 more sources
Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer [PDF]
, 1976 A cell line (HGC-27) was established by culture of the metastatic lymph node from a gastric cancer patient diagnosed histologically as undifferentiated carcinoma.
Akagi, Tadaatsu, Kimoto, Tetsuo
core +1 more source
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads [PDF]
, 2017 Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range.
Agard, Da +10 more
core +1 more source
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
Molecular & Cellular Oncology, 2020 We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
doaj +1 more source
Yeast and Viral RNA 5′ Triphosphatases Comprise a New Nucleoside Triphosphatase Family [PDF]
Journal of Biological Chemistry, 1998 Saccharomyces cerevisiae Cet1p catalyzes the first step of mRNA capping, the hydrolysis of the gamma phosphate of triphosphate-terminated RNA to form a 5' diphosphate end. The RNA triphosphatase activity of Cet1p is magnesium-dependent and has a turnover number of 1 s-1.
C K, Ho, Y, Pei, S, Shuman
openaire +2 more sources
Thyroid thermogenesis in adult rat hepatocytes in primary monolayer culture: direct action of thyroid hormone in vitro. [PDF]
, 1979 We have studied the effect of 3,5,3'-triiodothyronine (T3) on the respiration of adult rat hepatocytes in primary monolayer culture prepared from hypothyroid rat liver. After addition of T3 to the culture medium at a concentration of 2 x 10(-7) M, oxygen
Bissell, DM +2 more
core +2 more sources
International Journal of Occupational Medicine and Environmental Health, 2017 Objectives: To investigate whether postnatal benzo(a)pyrene (B(a)P) exposure caused the impairments on the process of neurodevelopment and the alteration in the calcium medium in the neonatal rats. Material and Methods: Eighty neonatal Sprague Dawley (SD)
Kai Yang +4 more
doaj +1 more source
The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme. [PDF]
PLoS ONE, 2013 Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5'-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de novo guanine nucleotide biosynthesis.
Frédéric Picard-Jean +3 more
doaj +1 more source