Results 251 to 260 of about 289,605 (341)

Prognostic Significance and Molecular Classification of Triple Negative Breast Cancer: A Systematic Review. [PDF]

Eur J Breast Health
Aziz OBA.
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Evaluation of Metaplastic Triple-Negative Breast Cancer Extracellular Matrix Structure and Protein Composition. [PDF]

Bioengineering (Basel)
Savoie JJ, Hebert KL, King CT, McConnell EC, Hoang VT, Monroe WT, Burow ME, Collins-Burow BM, Belgodere JA, Martin EC.   +9 more
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Precise Ratiometric Drug Delivery for the Treatment of Triple-Negative Breast Cancer. [PDF]

ACS Nano
Kang RH, Rasoulianboroujeni M, Kianpour M, Repp L, Ponik SM, Kwon GS.   +5 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Role of ERβ in Triple-Negative Breast Cancer Associated with p53 and Androgen Receptor. [PDF]

Int J Mol Sci
Ito K, Honma N, Ogata H, Yamada A, Miyashita M, Arai T, Sasaki E, Shibuya K, Mikami T, Sawaki M.   +9 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors for BRCA-associated early triple-negative breast cancer: progress and future hopes

Sh. R. Abdullaeva, Т. Yu. Semiglazova, A. S. Artemyeva, Татьяна Ивановна Севостьянова, Л. В. Филатова, В. В. Семиглазов, Petr Krivorotko, Semiglazov Vf   +7 more
openalex   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer. [PDF]

J Transl Med
Wang L, Zheng L, Yong X, Ding Z, Sun J, Tang Y, Tang K, Li Y, Chen J, Qi S, Hu H, Tang H.   +11 more
europepmc   +1 more source