Results 161 to 170 of about 101,408 (263)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Targeting B7-H3 in patients with metastatic triple-negative breast cancer and brain metastases: an opportunity to "revive" immunotherapy as a treatment strategy? [PDF]

J Immunother Cancer
Kojundzic I, Zatzman C, Belone Lopes J, Ramay R, Bayani J, Spears M, Jerzak KJ.   +6 more
europepmc   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Analysis of tumor-infiltrating lymphocytes as prognostic factor in triple-negative breast cancer: A protocol of systematic review and meta-analysis. [PDF]

PLoS One
Aquino LCM, Andrade EIS, Nunes LMF, Santos EM, Sarmento ACA, Medeiros KS, Gonçalves AK.   +6 more
europepmc   +1 more source

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study

Journal of Experimental Pharmacology
Muhammad Hasan Bashari,1 Mochamad Untung Kurnia Agung,2 Eko Fuji Ariyanto,1 Laode Muhammad Ramadhan Al Muqarrabun,3 Syefira Salsabila,3 Agus Chahyadi,3 Andi Rifki Rosandy,3 Ervi Afifah,4 Merry Afni,5 Harold Eka Atmaja,5 Tenny Putri,5 Fitria Utami,5 ...
Bashari MH, Agung MUK, Ariyanto EF, Al Muqarrabun LMR, Salsabila S, Chahyadi A, Rosandy AR, Afifah E, Afni M, Atmaja HE, Putri T, Utami F, Subhan B, Syafrizayanti, Andriani Y, Elfahmi   +15 more
doaj  

Beyond the Triple-Negative Label: A Case Report on Metaplastic Breast Carcinoma. [PDF]

Clin Case Rep
Oli S, Sapkota A, Khan SA, Rayamajhi A, Gupta D, Ghosh V, Karki D, Acharya R, Shrestha P.   +8 more
europepmc   +1 more source

CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma of the Breast

, 2018
AIMS: Mucoepidermoid carcinomas (MEC) are the most common malignant neoplasms of salivary glands but are uncommon in other sites. Salivary gland MEC are most frequently associated with CRTC1-MAML2 translocations.
Otis, Christopher
core  

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells. [PDF]

Int J Mol Med
Zhang Y, Wang L, Gao P, Sun Z, Li N, Lu Y, Shen J, Sun J, Yang Y, Dai H, Cai H.   +10 more
europepmc   +1 more source