Results 191 to 200 of about 171,342 (310)

Mammary metaplastic squamous cell carcinoma: a case report. [PDF]

J Med Case Rep
Tianqing Y, Guoliang Z, Shuqi L, Muyi Z, Yuanqi Z, Weiqiang L, Rong Z, Jiansen Y.   +7 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Inhibitory Effect of Interleukin-24 on Programmed Death Ligand 1 Expression via a Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2-Dependent Pathway in Human Triple-Negative Breast Cancer. [PDF]

Genes (Basel)
Smith S, Kim A, Sony A, Aslam M, Torruella E, de la Parra C, Sauane M.   +6 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Journal of Clinical Investigation, 2018
Jia Yu, Bo Qin, A. Moyer, S. Nowsheen, Tongzheng Liu, Sisi Qin, Yongxian Zhuang, Duan Liu, Shijia W. Lu, K. Kalari, D. Visscher, J. Copland, S. Mclaughlin, A. Moreno-Aspitia, D. Northfelt, R. Gray, Zhenkun Lou, V. Suman, R. Weinshilboum, J. Boughey, M. Goetz, Liewei Wang   +21 more
semanticscholar   +1 more source

Triple Negative Breast Cancer With Choroidal Metastasis Responsive to Sacituzumab Govitecan and Radiation Therapy. [PDF]

Cancer Rep (Hoboken)
Nafissi N, Mahadevan A, Chiao E, Rijal N, Parajuli R.   +4 more
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Imaging and Clinicopathological Features of Squamous Cell Metaplastic Breast Carcinoma: A 22-Case Retrospective Study. [PDF]

J Clin Med
Pan F, Liu L, Chen D, Peng Y.
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Nectin-4-Targeted Radiotheranostics for Personalized Cancer Therapy: A Systematic Review. [PDF]

J Nucl Med
Schäfer L, Altunay B, Morgenroth A, Vogg A, Derks Y, Lammers T, Peña Q, Mottaghy FM, Lütje S.   +8 more
europepmc   +1 more source