Results 131 to 140 of about 50,578 (264)

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Relevance of DNA tridimensional shape in RNA:DNA:DNA triple helix formation. [PDF]

Comput Struct Biotechnol J
Ferrero F, Leone A, Cicconetti C, Molineris I.   +3 more
europepmc   +1 more source

A solution structure analysis reveals a bent collagen triple helix in the complement activation recognition molecule mannan-binding lectin. [PDF]

J Biol Chem, 2023
Iqbal H, Fung KW, Gor J, Bishop AC, Makhatadze GI, Brodsky B, Perkins SJ.   +6 more
europepmc   +1 more source

The collagen triple helix [PDF]

Nature, 1974
D. S. JACKSON, M. E. GRANT
openaire   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Bridging the Gap: A Triple Helix Perspective on Interventions to Strengthen Seafarers' Mental Health. [PDF]

Inquiry
Bartusevičienė I, Yasmin F.
europepmc   +1 more source

Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis. [PDF]

Open Access Rheumatol, 2022
Nassef EM, Elabd HA, Elzomor HM, El Nagger BMMA, Ibrahim AS, Ibrahim AH, Kotb HG, Hassan DA, Abd ElAziz REM, Mohamed EES.   +9 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

A Neutral Triple-Helix Pomegranate (<i>Punica granatum</i>) Peel Polysaccharide with Lipid-Lowering and Prebiotic Activities. [PDF]

J Agric Food Chem
Shen HX, Shi L, Li YX, Zhang XY, Zhao CQ, Ma H, Lu YM.   +6 more
europepmc   +1 more source

A single natural RNA modification can destabilize a U•A-T-rich RNA•DNA-DNA triple helix. [PDF]

RNA, 2022
Kunkler CN, Schiefelbein GE, O'Leary NJ, McCown PJ, Brown JA.   +4 more
europepmc   +1 more source