Results 131 to 140 of about 52,288 (263)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Towards a Triple Helix based efficiency index of innovation systems. [PDF]

Scientometrics, 2022
Jovanović M, Savić G, Cai Y, Levi-Jakšić M.   +3 more
europepmc   +1 more source

Structural and Positional Effects of Peptoid Residues on Triple Helix Stability. [PDF]

Biomacromolecules
Ratnatilaka Na Bhuket P, Eastwood JRB, Qin Z, Kessler JL, Li Y, Katz D, Whitby FG, Hill CP, Kirshenbaum K, Yu SM.   +9 more
europepmc   +1 more source

Potential Universal Engineering Component: Tetracycline Response Nanoswitch Based on Triple Helix-Graphene Oxide. [PDF]

Micromachines (Basel), 2022
Wang L, Wang Y, Hu M, Xi S, Liu R, Cheng M, Dong Y.   +6 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Blackness unbound: autoethnography, culture, and global blackness through the Triple Helix Model. [PDF]

Front Sports Act Living
Williams AL.
europepmc   +1 more source

Evolution of Knowledge Structure in an Emerging Field Based on a Triple Helix Model: the Case of Smart Factory. [PDF]

J Knowl Econ, 2022
Liu D, Zhu YP.
europepmc   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Efficient expression of full-length triple-helix recombinant type III collagen in <i>Pichia pastoris</i>. [PDF]

Synth Syst Biotechnol
Li Q, Zhang J, Li Y, Yu H, Zhang J, Zhou J, Chen J, Guan X.   +7 more
europepmc   +1 more source

Analysis of low-carbon technology innovation efficiency and its influencing factors based on triple helix theory: Evidence from new energy enterprises in China. [PDF]

Heliyon, 2023
Guo Y, Bruno G, Zhang D, Han K.
europepmc   +1 more source