Results 141 to 150 of about 287,154 (333)

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer [PDF]

, 2020
Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Leung   +5 more
openalex   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer. [PDF]

, 2018
Triple-negative breast cancers (TNBC) lack estrogen and progesterone receptors and HER2 amplification, and are resistant to therapies that target these receptors.
Boymoushakian, Lari, Chiu, Alec M, Coller, Hilary A, Mitra, Mithun   +3 more
core  

Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis [PDF]

, 2021
McKay Mullen, Fengrui Yang, Jun Cao, Yang Cao, Xu Liu, Gee Young Lee, Tao Li, William Yao, Zhihong Yang, Jiahai Zhang, Kela Johnson, Felix Aikhionbare, Yong Chen, Xinjiao Gao, Dongmei Wang, Xia Ding, Hadiyah-Nicole Green, Xing Liu, Xuebiao Yao, Xing Liu, Xuebiao Yao   +20 more
openalex   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Triple-negative breast cancer: new options for systemic targeted therapy. A review [PDF]

, 2022
Д. А. Андреев, A. A. Zavyalov
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Long non-coding RNA AC099850.4 correlates with advanced disease state and predicts worse prognosis in triple-negative breast cancer [PDF]

, 2023
Radhakrishnan Vishnubalaji, Nehad M. Alajez   +1 more
openalex   +1 more source

A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids

Advanced Healthcare Materials, EarlyView.
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova, Fatemeh Ahmadi, Jennifer Cruickshank, Zheyuan Miao, David W. Cescon, Eugenia Kumacheva   +5 more
wiley   +1 more source