Results 171 to 180 of about 287,154 (333)

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Molecular profiling of breast cancer methylation pattern in triple negative versus non- triple negative breast cancer

Scientific Reports
Epigenetic alterations, especially promotor methylation, have a significant impact on gene expression, molecular subtyping, prognosis, and outcome of breast cancer (BC). The methylation profile was assessed for 22 genes of the BC tissue using the EpiTect
Marwa Mohanad, Hager M. Hamza, Abeer A. Bahnassy, Sabry Shaarawy, Ola Ahmed, Hatem A. EL-Mezayen, Eman G. Ayad, Neveen Tahoun, Mona S. Abdellateif   +8 more
doaj   +1 more source

Integrative analysis of lncRNAs and miRNAs with coding RNAs associated with ceRNA crosstalk network in triple negative breast cancer

, 2017
Naijun Yuan, Guijuan Zhang, Fengjie Bie, Min Ma, Yi Ma, Xuefeng Jiang, Yurong Wang, Xiaoqian Hao   +7 more
openalex   +2 more sources

The Omega-3 Docosahexaenoyl Ethanolamide Reduces CCL5 Secretion in Triple Negative Breast Cancer Cells Affecting Tumor Progression and Macrophage Recruitment [PDF]

, 2023
Giuseppina Augimeri, Marco Fiorillo, Catia Morelli, Salvatore Panza, Cinzia Giordano, Ines Barone, Stefania Catalano, Diego Sisci, Sebastiano Andò, Daniela Bonofiglio   +9 more
openalex   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway

, 2019
Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai, Jianchao He   +4 more
openalex   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

, 2020
Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin, Sue Eccles, Per Christian Sontum, Spiros Kotopoulis, Svein Kvåle, Annemieke van Wamel, Catharina de Lange Davies, Jeffrey C. Bamber   +11 more
openalex   +1 more source

In vivo CRISPR screens identify RhoV as a pro‐metastasis factor of triple‐negative breast cancer [PDF]

, 2023
Ming‐Liang Jin, Yue Gong, Peng Ji, Xin Hu, Zhi‐Ming Shao   +4 more
openalex   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source