Results 61 to 70 of about 112,151 (292)

Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

Genome Biology, 2022
Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality.
Stephen J. Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C. Marioni, Jennifer Nichols, Wolf Reik   +8 more
doaj   +1 more source

Is There a Planet in the PSR 1620-26 Triple System?

, 1994
The unusually large eccentricity ($e_1=0.025$) of the low-mass binary millisecond pulsar PSR B1620-26 can be explained naturally as arising from the secular perturbation of a second, more distant companion.
Rasio, F. A.
core   +1 more source

Relativistic Coupled Cluster with Completely Renormalized and Perturbative Triples Corrections

The Journal of Physical Chemistry A
We have implemented noniterative triples corrections to the energy from coupled-cluster with single and double excitations (CCSD) within the 1-electron exact two-component (1eX2C) relativistic framework. The effectiveness of both the CCSD(T) and the completely renormalized (CR) CC(2,3) approaches are demonstrated by performing all-electron computations
Stephen H. Yuwono, Run R. Li, Tianyuan Zhang, Kshitijkumar A. Surjuse, Edward F. Valeev, Xiaosong Li, A. Eugene DePrince   +6 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stress Concentration and Distribution at Triple Junction Pores of Three-Fold Symmetry in Ceramics

Reviews on Advanced Materials Science, 2018
The stress concentration and distribution around a triple-junction pore of three-fold symmetry in a polycrystalline ceramic material is considered.
Vakaeva A.B., Krasnitckii S.A., Smirnov A.M., Grekov M.A., Gutkin M.Yu.   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Modified evolution of stellar binaries from supermassive black hole binaries

, 2017
The evolution of main sequence binaries resided in the galactic centre is influenced a lot by the central super massive black hole (SMBH). Due to this perturbation, the stars in a dense environment are likely to experience mergers or collisions through ...
Liu, Bin, Wang, Yi-Han, Yuan, Ye-Fei
core   +1 more source

Post-Wick theorems for symbolic manipulation of second-quantized expressions in atomic many-body perturbation theory [PDF]

, 2009
Manipulating expressions in many-body perturbation theory becomes unwieldily with increasing order of the perturbation theory. Here I derive a set of theorems for efficient simplification of such expressions.
Andrei Derevianko, Fetter A L, Fritzsche S, Lindgren I, Szabo A, Veltman M Williams D N   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source