Results 81 to 90 of about 18,191 (257)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Effect of volume fractions and aging on Ni-GDC SOFC anode degradation and performance: multiphase-field simulations

npj Materials Degradation
Enhancing the performance and durability of solid oxide fuel cells (SOFCs) requires concurrent improvements in electrochemical activity and mechanical integrity, both strongly dependent on the initial anode microstructure and its degradation over long ...
Ravi Kumar Jeela, Ahmed Elmoghazy, Lukas Schöller, Matthias Wieler, Andreas Prahs, Daniel Schneider, Britta Nestler   +6 more
doaj   +1 more source

Investigation of microstructural evolution in sintered NdFeB during the two-step annealing

Journal of Materials Research and Technology
Two-step annealing is an effective approach for enhancing coercivity of sintered NdFeB magnets. In-situ transmission electron microscopy (in-situ TEM) were utilized to figure out the microstructural evolution in two-step annealing.
Zihao Wang, Haijun Yu, Shengen Guan, Yang Zheng, Xiaoqian Bao, Jiheng Li, Xuexu Gao   +6 more
doaj   +1 more source

Geometry of polycrystals and microstructure

MATEC Web of Conferences, 2015
We investigate the geometry of polycrystals, showing that for polycrystals formed of convex grains the interior grains are polyhedral, while for polycrystals with general grain geometry the set of triple points is small.
Ball John M., Carstensen Carsten
doaj   +1 more source

Phase structure of the twisted SU(3)/U(1)2 flag sigma model on ℝ × S 1

Journal of High Energy Physics, 2019
We investigate the phase structure of the compactified 2-dimensional nonlinear SU(3)/U(1)2 flag sigma model with respect to two θ-terms. Based on the circle compactification with the ℤ3-twisted boundary condition, which preserves an ’t Hooft anomaly of ...
Masaru Hongo, Tatsuhiro Misumi, Yuya Tanizaki   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Electrochemically driven C-N bond formation from CO₂ and ammonia at the triple-phase boundary. [PDF]

Chem Sci, 2022
Li J, Kornienko N.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Interaction Regulation Between Ionomer Binder and Catalyst: Active Triple-Phase Boundary and High Performance Catalyst Layer for Anion Exchange Membrane Fuel Cells. [PDF]

Adv Sci (Weinh), 2021
Cao H, Pan J, Zhu H, Sun Z, Wang B, Zhao J, Yan F.   +6 more
europepmc   +1 more source