Results 61 to 70 of about 18,191 (257)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Triple-Layer Porous Transport Layers with Ultra-High Porosity for Enhanced Oxygen Transport and Catalyst Utilization in Water Electrolysis

Nano-Micro Letters
Highlights A novel triple-layer Ti-porous transport layer (PTL), fabricated using a practical and scalable tape casting and roll calendering process, enhances catalyst utilization by increasing interfacial contact area and the triple-phase boundary.
Seong Hyun Park, Young Je Park, Seungsoo Jang, Pilyoung Lee, Soobin Yoon, Young-June Park, Chi-Young Jung, Kang Taek Lee   +7 more
doaj   +1 more source

Hydrophobicity engineering of hierarchically ordered SiO2/Fe-N-C catalyst with optimized triple-phase boundary for boosting oxygen reduction reaction

Nano Research Energy
The Fe single-atom catalyst (Fe-N-C) with Fe-Nx active sites is considered a promising alternative to Pt-based catalysts for oxygen reduction reaction (ORR).
Yang Zhang, Bingbing Gong, Benji Zhou, Zhibo Liu, Nengneng Xu, Yongxia Wang, Xiaoqian Xu, Qing Cao, Daniil I. Kolokolov, Haitao Huang, Shuaifeng Lou, Guicheng Liu, Woochul Yang, Jinli Qiao   +13 more
doaj   +1 more source

Superoxide generation from the reduction of oxygen at the carbon–oil–water triple phase boundary

Physical Chemistry Chemical Physics, 2013
The reduction of oxygen is studied in aqueous solutions of pH 6.22-8.01, at a carbon paste electrode fabricated from dioctyl phthalate (oil) and graphite. Two two-electron voltammetric waves are usually seen on carbon electrodes, associated with the formation of hydrogen peroxide and water, respectively.
Nissim, R, Compton, R
openaire   +3 more sources

Theory-based design of sintered granular composites triples three-phase boundary in fuel cells [PDF]

Physical Review E, 2017
Solid-oxide fuel cells produce electric current from energy released by a spontaneous electrochemical reaction. The efficiency of these devices depends crucially on the microstructure of their electrodes and in particular on the three-phase boundary (TPB) length, along which the energy-producing reaction occurs.
Shahar Amitai, Antonio Bertei, Raphael Blumenfeld   +2 more
openaire   +5 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Coupled Triple Phase Boundary Processes: Liquid | Liquid Generator - Collector Electrodes

Electrochemistry Communications, 2010
Peer ...
Vagin, Mikhail Yu, Karyakin, Arkady A., Vuorema, Anne, Sillanpaa, Mika, Meadows, Helen, Campo García, Francisco Javier del, Cortina-Puig, Montserrat, Bulman Page, Phillip C., Chan, Yohan, Marken, Frank   +9 more
openaire   +4 more sources

Silicon carbide hot pressing sintered by magnesium additive: microstructure and sintering mechanism

Journal of Materials Research and Technology, 2020
Silicon carbide was hot pressing sintered at 1300 ̊C/30 MPa by using magnesium additive. Microstructure and sintering mechanism are studied. Result shows that the hot pressing sintered sample composed of both α-SiC and β-SiC, indicating that no polytype ...
Jingkun Li, Xueping Ren, Yanling Zhang, Hongliang Hou   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source