Results 41 to 50 of about 19,369 (259)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Precipitation Behavior of O Phase during Continuous Cooling of Ti-22Al-25Nb Alloy

Metals, 2022
The microstructure evolution and formation mechanism of the O phase in a Ti-22Al-25Nb (at.%) orthorhombic alloy resulting from different cooling rates were investigated.
Dong Li, Weidong Zeng, Fan Zhang, Jianwei Xu, Xiong Ma, Xiaobo Liang   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Design of Mixed Ionic-Electronic Materials for Permselective Membranes and Solid Oxide Fuel Cells Based on Their Oxygen and Hydrogen Mobility

Membranes, 2023
Oxygen and hydrogen mobility are among the important characteristics for the operation of solid oxide fuel cells, permselective membranes and many other electrochemical devices.
Vladislav Sadykov, Elena Pikalova, Ekaterina Sadovskaya, Anna Shlyakhtina, Elena Filonova, Nikita Eremeev   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Nucleation and evolution of β phase and corresponding intergranular corrosion transition at 100–230 °C in 5083 alloy containing Er and Zr

Materials & Design, 2019
The intergranular corrosion and β phase evolution of 5083 aluminum alloy containing Er and Zr during annealing at 100–230 °C were studied using mass loss tests and transmission electron microscopy.
Yusheng Ding, Kunyuan Gao, Hui Huang, Shengping Wen, Xiaolan Wu, Zuoren Nie, Shanshan Guo, Rui Shao, Cheng Huang, Dejing Zhou   +9 more
doaj   +1 more source

Design of triple and quadruple phase boundaries and chemistries for environmental SO ₂ electrochemical sensing

Journal of Materials Chemistry A, 2021
Favorably engineering sensing reaction zones from triple phase boundaries to quadrupole phase boundaries towards enriching the functionality of the Li-garnet Li 7 La 3 Zr 2 O 12
Moran Balaish, Jennifer L. M. Rupp
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source