Results 51 to 60 of about 18,191 (257)

Precipitation Behavior of O Phase during Continuous Cooling of Ti-22Al-25Nb Alloy

Metals, 2022
The microstructure evolution and formation mechanism of the O phase in a Ti-22Al-25Nb (at.%) orthorhombic alloy resulting from different cooling rates were investigated.
Dong Li, Weidong Zeng, Fan Zhang, Jianwei Xu, Xiong Ma, Xiaobo Liang   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Design of Mixed Ionic-Electronic Materials for Permselective Membranes and Solid Oxide Fuel Cells Based on Their Oxygen and Hydrogen Mobility

Membranes, 2023
Oxygen and hydrogen mobility are among the important characteristics for the operation of solid oxide fuel cells, permselective membranes and many other electrochemical devices.
Vladislav Sadykov, Elena Pikalova, Ekaterina Sadovskaya, Anna Shlyakhtina, Elena Filonova, Nikita Eremeev   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Nucleation and evolution of β phase and corresponding intergranular corrosion transition at 100–230 °C in 5083 alloy containing Er and Zr

Materials & Design, 2019
The intergranular corrosion and β phase evolution of 5083 aluminum alloy containing Er and Zr during annealing at 100–230 °C were studied using mass loss tests and transmission electron microscopy.
Yusheng Ding, Kunyuan Gao, Hui Huang, Shengping Wen, Xiaolan Wu, Zuoren Nie, Shanshan Guo, Rui Shao, Cheng Huang, Dejing Zhou   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Microstructural features of Mg-8%Sn alloy and its correlation with mechanical properties

Journal of Magnesium and Alloys, 2017
The aim of this investigation is to establish a structure-property correlation of Mg-8%Sn alloys aged at different time interval. The alloy under the present investigation was aged at elevated (200 °C) temperature for various holding period.
Palash Poddar, Ashok Kamaraj, A.P. Murugesan, Sumanta Bagui, K.L. Sahoo   +4 more
doaj   +1 more source

Design of triple and quadruple phase boundaries and chemistries for environmental SO ₂ electrochemical sensing

Journal of Materials Chemistry A, 2021
Favorably engineering sensing reaction zones from triple phase boundaries to quadrupole phase boundaries towards enriching the functionality of the Li-garnet Li 7 La 3 Zr 2 O 12
Moran Balaish, Jennifer L. M. Rupp
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source