Results 101 to 110 of about 200,653 (263)

Exploration of the hierarchical assembly space of collagen-like peptides beyond the triple helix

Nature Communications
The de novo design of self-assembling peptides has garnered significant attention in scientific research. While alpha-helical assemblies have been extensively studied, exploration of polyproline type II helices, such as those found in collagen, remains ...
Le Tracy Yu, Mark A. B. Kreutzberger, Thi H. Bui, Maria C. Hancu, Adam C. Farsheed, Edward H. Egelman, Jeffrey D. Hartgerink   +6 more
doaj   +1 more source

Spectral analysis of second order quantum difference operator over the sequence space lp (1 < p < ∞)

Қарағанды университетінің хабаршысы. Математика сериясы
In this article, we study the spectrum, fine spectrum and boundedness property of second order quantum difference operator ∆2q (0 < q < 1) over the class of sequence lp (1 < p < ∞), the pth summable sequence space.
N. Kalita, A.J. Dutta
doaj   +1 more source

Good sequencings for small Mendelsohn triple systems

, 2019
A Mendelsohn triple system of order $v$ (or MTS$(v)$) is a decomposition of the complete graph into directed 3-cyles. We denote the directed 3-cycle with edges $(x,y)$, $(y,z)$ and $(z,x)$ by $(x,y,z)$, $(y,z,x)$ or $(z,x,y)$. An $\ell$-good sequencing of a MTS$(v)$ is a permutation of the points of the design, say $[x_1 \; \cdots \; x_v]$, such that ...
Kreher, Donald L., Stinson, Douglas R., Veitch, Shannon   +2 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Triple sequences and their statistical convergence

, 2007
Pringsheim gave the definition of the convergence for double sequences in 1900. The idea of statistical convergence was first presented by Fast in 1951. In 2003 Tripathy and Mursaleen et.al introduced statistical convergence of double sequences. In this article we introduce the notions of triple sequences and statistically convergent triple sequence ...
FATMA KADRİYE, DÜDEN, ŞAHİNER, Ahmet, GÜRDAL, Mehmet   +2 more
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source