Results 41 to 50 of about 151,472 (303)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2023 Transient transfection of mammalian cells using plasmid DNA is a standard method to produce adeno-associated virus (AAV) vectors allowing for flexible and scalable manufacture.
Laura P. van Lieshout +25 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Radiology Case Reports, 2023 The first case of synovial sarcoma was published in 1893. The disease is a type of primary malignancy of the soft tissues. It is a rare and aggressive neoplasm of unknown tissue origin, characterized by strong metastatic potential and poor prognosis. The
Aleksandar A. Georgiev, PhD +4 more
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Block-avoiding point sequencings of directed triple systems [PDF]
Discrete Mathematics, 2020 A directed triple system of order $v$ (or, DTS$(v)$) is decomposition of the complete directed graph $\vec{K_v}$ into transitive triples. A $v$-good sequencing of a DTS$(v)$ is a permutation of the points of the design, say $[x_1 \; \cdots \; x_v]$, such that, for every triple $(x,y,z)$ in the design, it is not the case that $x = x_i$, $y = x_j$ and $z
Donald L. Kreher +2 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Triple HIV-1 Infection Is Associated With Faster CD4+ T-Cell Decline
Frontiers in Microbiology, 2020 HIV-1 dual infection occurs when an individual is simultaneously or sequentially infected with two or more genetically distinct HIV-1 strains. According to the number of infected strains, HIV-1 dual infection can be divided in double infection and triple
Yu Zhang +10 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Regular matrix transformation on triple sequence spaces - I
MATHEMATICA, 2017 The main aim of this paper is to introduce the necessary and sufficient condition for a particular type of transformation of the form A: (a......) be regular from a triple sequence space to another triple sequence space.
Shyamal Debnath, Bimal Chandra Das
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