Results 41 to 50 of about 1,723 (256)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Waveguide diode frequency tripler 75-110 GHz calculation and design practice
Физика волновых процессов и радиотехнические системы, 2015 Waveguide diode frequency tripler in the range of 75 to 110 GHz calculation and design method, based on using HFSS and Designer programs, combining electrodynamic waveguide structures and nonlinear characteristics analysis, was proposed.
V.V. Berezin, A.M. Schitov
doaj
Arthroscopy Techniques, 2021 Anterior cruciate ligament reconstruction failure remains a commonly seen outcome despite advances in technique and graft options. Recent studies have shown that the declination of the tibial plateau slope in the sagittal plane affects the in situ stress
CPT Christian A. Cruz, M.D. +5 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
New magnetic frequency tripler with delta connection suited for high power unit
, 1979 A magnetic frequency tripler having a new configuration is proposed. The tripler is composed of three series-connected reactor circuits connected in delta. Because a triple frequency current circulates in delta-connection and does not flow into the input
Ohyama, K. +6 more
core +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Acute eosinophilic pneumonia following electronic cigarette use
Respiratory Medicine Case Reports, 2019 Electronic cigarette (e-cigarette) use, or vaping, is gaining widespread popularity among adults aged 18–35. Vaping is commercially promoted as a safer alternative to traditional cigarette smoking.
Zhaohui L. Arter +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A High-Harmonic-Rejection W-Band Mixer-Based Frequency Tripler With a Dual-Mode Notch Filter
IEEE Journal of MicrowavesThis paper presents a W-band mixer-based frequency tripler featuring a dual-mode notch filter (DMNF) that simultaneously suppresses fundamental ($f{_{0}}$) and second harmonic (2$f{_{0}}$) while boosting the desired third harmonic (3$f{_{0}}$), enabling ...
Dongho Yoo, Byung-Wook Min
doaj +1 more source