Results 111 to 120 of about 1,896 (221)

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Thermo-hydraulic performance of uniform and hybrid Triply Periodic Minimal Surfaces (TPMS) heat exchangers

Proceedings of the Holistic Innovation in Additive Manufacturing (HI-AM) Conference
Triply Periodic Minimal Surfaces (TPMS) geometries are remarkable solutions for achieving optimal heat transfer performance in industries where space-efficient cooling solutions are required. Utilizing these additively manufactured geometries in Heat Exchanger (HX) applications involves a trade-off between maximizing heat transfer and minimizing ...
Armin Hassanirad, Collins Chike Kwasi-Effah, Osezua Ibhadode   +2 more
openaire   +1 more source

Simultaneous Establishment of Autologous Colorectal Cancer and Mesothelial Stromal Cell Lines from Malignant Ascites Reveals a Mesothelial‐Stromal FGFR3 Axis as a Potential Vulnerability in Peritoneal Metastasis

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Colorectal cancer (CRC) with peritoneal dissemination remains a major therapeutic challenge because of poor prognosis and limited treatment options. Experimental models that accurately recapitulate tumor–mesothelial interactions are scarce. Here, we report the establishment of a novel autologous paired model comprising a CRC cell line (OMUCR‐1)
Yasuhiro Fukui, Hiroaki Kasashima, Zizhou Wang, Iguru Omori, Yukina Kusunoki, Kanae Echizen, Yoshiki Nonaka, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Yu Muta, Yuki Nakanishi, Masakazu Yashiro, Naoko Ohtani, Kiyoshi Maeda   +19 more
wiley   +1 more source

Mechanical properties of ceramic structures based on Triply Periodic Minimal Surface (TPMS) processed by 3D printing

Journal of Physics: Conference Series, 2017
Repairing tissues and organs has been the main goal of surgical procedures. Since the 1990s, the main goal of tissue engineering has been reparation, using porous scaffolds that serve as a three-dimensional template for the initial fixation of cells and subsequent tissue formation both in vitro and in vivo. A scaffold must have specific characteristics
S Restrepo, S Ocampo, J A Ramírez, C Paucar, C García   +4 more
openaire   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Permeability and microstructural parameters of 3D‐printed triply periodic minimal surface (TPMS) hydroxyapatite scaffolds

Journal of the American Ceramic Society
Abstract The search for designing and fabricating truly tissue‐like scaffolds is one of the grand challenges in bone tissue engineering. The question on which parameters are actually the most representative of scaffold architecture and, thus, have to be more carefully designed and considered for assessing the scaffold suitability ...
Roberta Gabrieli, Alessandro Schiavi, Francesca Romana Pennecchi, Dario Alidoost, Martin Schwentenwein, Luca D'Andrea, Pasquale Vena, Enrica Verné, Francesco Baino   +8 more
openaire   +1 more source

Oridonin‐Loaded PDA@Gel@GO Nanocapsules Modulate NLRP3 and Epithelial Repair in Colitis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Mechanism of galactosylated carboxymethyl chitosan nanomicelle oral microcapsules delivering oridonin in alleviating colitis via targeting the NLRP3 inflammasome. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD‐like
Wenbo Yuan, Qirui Zhao, Jing Hua, Lingyao Xu, Yufan Wang, Tongtong Xu, Zuchao Du, Liping Wu, Daxiang Cui   +8 more
wiley   +1 more source

Electrical Tortuosities of Porous Structures Based on Triply Periodic Minimal Surfaces and Honeycombs for Power-to-Heat Systems

Energies
Power-to-heat (P2H) systems offer an efficient solution for decarbonization by facilitating the integration of renewable energy into the industrial, heating, and transport sectors.
Thorsten Ott, Volker Dreißigacker
doaj   +1 more source

Osteoconductive Lightweight Scaffolds for Bone Tissue Engineering [PDF]

Bone tissue engineering is a rapidly advancing field, aiming to develop alternatives to traditional auto- and allografts for bone regeneration. Among a wide variety of materials that exist, calcium phosphates remain one of the most promising due to their
Maevskaia, Ekaterina
core   +1 more source

Enhancing heat transfer across applications with triply periodic minimal surface (TPMS) structures: A comprehensive review

Chemical Engineering and Processing - Process Intensification
The current research evaluates how triply periodic minimal surface (TPMS) structures, specifically Gyroid configurations, enhance heat transfer in thermal management systems by addressing heating issues caused by miniaturized electronic devices. TPMS structures composed of Gyroid and Fischer-Koch varieties demonstrate up to a 50.6 % improvement in ...
Farhan Lafta Rashid, Najah M.L. Al Maimuri, Mudhar A. Al-Obaidi, Muhammad Asmail Eleiwi, Arman Ameen, Shabbir Ahmad, Atef Chibani, Mohamed Kezzar, Ephraim Bonah Agyekum   +8 more
openaire   +2 more sources