Results 171 to 180 of about 1,682,449 (357)
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Equilibrium analysis and LSER modelling for extraction of Trans-aconitic acid using Tri-butyl Phosphate by using Xylene and Benzene [PDF]
Rishikesh Nimbalkar +2 more
openalex +1 more source
Utilização da gema de ovo de diferentes espécies e proporções sobre a conservação do sêmen congelado de ovinos da raça. [PDF]
Resumo: Objetivou-se verificar a utilização da gema de ovo de diferentes espécies e sua taxa de adição (10% e 20%) sobre as características de motilidade do sêmen congelado de carneiro.
ARAÚJO, A. A. de +7 more
core
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
De l"utilisation du tri pour augmenter le rendement d"un procede d"assemblage [PDF]
F. Bourgeois +3 more
openalex
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Die allgemeine Dynamik der abenđlandischen Zivilisation erbrachte die Ausbildung folgender drei Grundbedeutungen der modernen Kultur: autklarende Bedeutung, die der Pionierzeit des Eurozentrismus und seiner universalistischen Mission entspricht; nationale Bedeutung, die aus der europaischen Halbperipherie im 19.
openaire +3 more sources
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source

