Results 51 to 60 of about 1,412,782 (341)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Tubulo-reticular inclusions in lupus nephritis: Are they relevant?

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2014
Tubulo-reticular inclusions (TRIs) are organized subcellular structures that may be found in endothelial cells of patients with systemic lupus erythematosus (SLE).
Hala Kfoury
doaj   +1 more source

High-efficiency organic electrophosphorescent devices with tris(2-phenylpyridine)iridium doped into electron-transporting materials

open access: yes, 2000
We demonstrate high-efficiency organic light-emitting devices employing the green electrophosphorescent molecule, fac tris(2-phenylpyridine)iridium [Ir(ppy)3], doped into various electron-transport layer (ETL) hosts.
C. Adachi   +3 more
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

Mood and modal concord in Spanish directive clauses

open access: yesBorealis: An International Journal of Hispanic Linguistics
According to Faulkner (2022b), in the case of Spanish, “indicative directive complements are strongly preferable to subjunctive clauses when a weak necessity and teleological matrix directive embeds a modal verb of equivalent strength and type” (p.
Tris Faulkner
doaj   +1 more source

Tri-comb spectroscopy [PDF]

open access: yesNature Photonics, 2018
Multi-dimensional coherent spectroscopy (MDCS)1,2 is a powerful method for optical spectroscopy that has become an important tool for studying ultrafast dynamics in a wide range of systems. It is an optical analog of multidimensional nuclear magnetic resonance spectroscopy that enables the measurement of homogeneous linewidths in inhomogeneously ...
Bachana Lomsadze   +3 more
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Influence of butylated hydroxytoluene addition to cryodiluents on freezability and DNA integrity of Boer and Zaraibi buck spermatozoa

open access: yesAsian Pacific Journal of Reproduction, 2020
Objective: To evaluate the cryoprotective effect of butylated hydroxytoluene on buck frozen semen. Methods: Semen was collected from Boer (n=6) and Zaraibi (n=6) bucks by electroejaculator for 5 weeks.
Ahmed R. M. El-Khawagah   +3 more
doaj   +1 more source

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