Results 31 to 40 of about 614,667 (265)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

SOME PHYSICOCHEMICAL PROPERTIES OF OCTYLPHENOL ETHOXYLATE NONIONICS (TRITON X-100, TRITON X-114 AND TRITON X-405) AND THE TEMPERATURE EFFECT ON THIS PROPERTIES

Trakya University Journal of Natural Sciences, 2016
Surface tensions and condutvities of aqueous solutions of nonionic surfactants at various concentrations were measured at diffferent temperatures.The critical micelle concentration (CMC) of aqueous solutions of three different octylphenol ethoxylate ...
Taliha Sidim
doaj   +6 more sources

A process–structure–property ICME framework for additive friction stir deposition repair of aluminum alloys

Materials & Design
Additive Friction Stir Deposition (AFSD) is a novel solid-state additive manufacturing process that is particularly suitable for repair of aluminum alloys.
Hamza Jabbar, Abigail Taylor, Farid Biniyazan, Jack Grubbs, Bryer Sousa, Sadie Beck, Qiaofu Zhang   +6 more
doaj   +1 more source

Effect of Green Synthesized Iron Oxide Nanoparticles Using Spinach Extract on Triton X-100-Induced Atherosclerosis in Rats

Biochemistry Research International, 2022
The effect of iron oxide nanoparticles (FeONPs) synthesized using Spinacia oleracea leaf extract on Triton X-100-induced atherosclerosis in white Wistar rats was determined.
Habila Obidah Abert, Hauwa Umaru Aduwamai, Saminu Shehu Adamu   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of experimental hepatic steatosis on apelin and various biochemical parameters in male white rabbits

Open Veterinary Journal
Background: Hepatic steatosis is the second most prevalent liver disease following viral hepatitis, and its incidence is increasing rapidly, posing a significant threat to human health.
Rana Suhail AL-Juwary, Muntaha Mahmood AL-Kattan   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

EFFECT OF GARLIC AND ATORVASTATIN ON LEPTIN AND LIPID PROFILE IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS [PDF]

Kafrelsheikh Veterinary Medical Journal, 2014
Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases. This study was conducted to determine the effect of Garlic on  Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats ...
Nabil M. Taha, Ahmed Z. Abdalaziz, Kadry M. Sadek, Hatem S. Abdel-Hamid   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339

Journal of Lipid Research, 2005
Triglyceride (TG), a water-insoluble energy-rich lipid, is secreted by the liver as part of very low density lipoproteins (VLDLs) to supply energy to extrahepatic tissues.
John S. Millar, Debra A. Cromley, Mary G. McCoy, Daniel J. Rader, Jeffrey T. Billheimer   +4 more
doaj   +1 more source