Results 81 to 90 of about 890,870 (301)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF AUTOMATIC LAYER-BY-LAYER SEGMENTATION USING OPTICAL COHERENT TOMOGRAPHS DRI OCT AND RETINASCAN-3000 IN HEALTHY PATIENTS

Oftalʹmologiâ, 2017
The aim was to determine different possibilities and the operating principle of modern optical coherent tomographs OCT RETINASCAN-3000 and  DRI OCT TRITON in automatic layer-by-layer segmentation of the  retina  and  perioretinal  structures.
M. M. Bikbov, R. R. Fayzrakhmanov, T. R. Gil’manshin, R. M. Zainullin, R. I. Hikmatullin, M. R. Kalanov   +5 more
doaj   +1 more source

Low-momentum interactions with smooth cutoffs

, 2006
Nucleon-nucleon potentials evolved to low momentum, which show great promise in few- and many-body calculations, have generally been formulated with a sharp cutoff on relative momenta.
A. Schwenk, Amado, Andreozzi, Birse, Bogner, Bogner, Bogner, Bogner, Bogner, Bogner, Bogner, Bogner, Entem, Epelbaoum, Epelbaum, Epelbaum, Friar, Fujii, Giraud, Holt, Latorre, Lee, Lepage, Liao, Nakamura, Navratil, Nogga, Okubo, Press, R.J. Furnstahl, S. Ramanan, S.K. Bogner, Schwenk, Suzuki, Suzuki, Viviani, Weinberg, Wiringa, Wloch   +38 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Physiological and biochemical effects of experimental hepatic steatosis in male albino rabbits

Bulgarian Journal of Veterinary Medicine
The current research detected effect of polyphenols extracted from strawberries, omega-3 extracted from almonds, and a combination of omega-3 and vitamin E in reducing the risk of experimental liver steatosis induced by Triton.
R. S. AL-Juwary, M. M. AL-Kattan
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice

Toxicology Reports, 2014
Chrysin (5,7-dihydroxyflavone) is a flavonoid, natural component of traditional medicinal herbs, present in honey, propolis and many plant extracts. The objective of this study was to investigate the hypolipidemic properties of chrysin on Triton WR-1339 ...
Micheli Stéfani Zarzecki, Stífani M. Araujo, Vandreza C. Bortolotto, Mariane Trindade de Paula, Cristiano Ricardo Jesse, Marina Prigol   +5 more
doaj   +1 more source

Embedding nuclear physics inside the unitary window

, 2019
The large values of the singlet and triplet scattering lengths locate the two-nucleon system close to the unitary limit, the limit in which these two values diverge.
Gattobigio, Mario, Kievsky, Alejandro, Viviani, Michele   +2 more
core   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source