Results 241 to 250 of about 44,808,645 (302)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Validation of a Lysis Buffer Containing 4 M Guanidinium Thiocyanate (GITC)/ Triton X-100 for Extraction of SARS-CoV-2 RNA for COVID-19 Testing: Comparison of Formulated Lysis Buffers Containing 4 to 6 M GITC, Roche External Lysis Buffer and Qiagen RTL Lysis Buffer

, 2020
Scallan MF, Dempsey C, MacSharry J, O’Callaghan I, O’Connor PM, Horgan CP, Durack E, Cotter PD, Hudson S, Moynihan HA, Lucey B.   +10 more
europepmc   +1 more source

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Activation of acetylcholinesterase by Triton X-100

Biochimica et Biophysica Acta (BBA) - Enzymology, 1972
Abstract The effect of Triton X-100 on human brain acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) was studied with reference to its solubilization and the solubilization products which were analyzed by acrylamide gel electrophoresis. The particulate activity remained virtually constant at various Triton X-100 levels despite solubilization
R, Srinivasan, A, Karczmar, J, Bernsohn
openaire   +2 more sources

Capillary electrochromatography of Triton X‐100

ELECTROPHORESIS, 2004
AbstractNonionic surfactants such as Triton X‐100 (TX‐100) are comprised of a mixture of oligomers with a varying degree of length in the ethoxylate chain. The development of chromatographic methods for resolution of the various oligomers of TX‐100 is of environmental importance, and can be useful for quality control and characterization in industrial ...
Dean, Norton, Shahab A, Shamsi
openaire   +2 more sources

Permeabilization of microorganisms by Triton X-100

Analytical Biochemistry, 1978
Abstract A simple permeabilization procedure has been developed which allows the reliable determination of enzyme activitiesin situ in a variety of different microorganisms. Permeabilization is obtained by freezing cell suspensions in the presence of a low concentration of the anionic detergent Triton X-100.
G F, Miozzari, P, Niederberger, R, Hütter   +2 more
openaire   +2 more sources

Enzymatic sulfation of Triton X-100

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
Triton X-100 increased incorporation of [35S]sulfate into lipid-soluble substances when it was incubated with the high-speed supernatant enzymes of bovine or sheep adrenal cortex or rat liver, kidney or brain. Thin-layer chromatographic comparison of these compounds with chemically synthesized standards indicated that sulfate derivatives of Triton X ...
L, Spolter, L I, Rice
openaire   +2 more sources

Solubilization of sarcoplasmic reticulum with Triton X-100

Archives of Biochemistry and Biophysics, 1971
The nonionic detergent Triton X-100 has been found to solubilize approximately 80% of the protein, and nearly all the phospholipid from sarcoplasmic reticulum membranes. The soluble fraction contains Ca 2+ dependent ATPase, but no basic ATPase activity. In comparative experiments, Triton X-100 causes much less enzyme denaturation than ionic detergents.
B H, McFarland, G, Inesi
openaire   +2 more sources

The purification of cardiac myofibrils with Triton X-100

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1971
Abstract Cardiac myofibrils treated with 1% Triton X-100 are virtually free of contamination by mitochondrial, sarcolemmal and sarcoplasmic reticular membranes. The ATPase activity of such myofibrils corresponds closely to that reported for cardiac actomyosin and the sensitivity of this ATPase activity to calcium control is normal.
R J, Solaro, D C, Pang, F N, Briggs
openaire   +2 more sources