Results 291 to 300 of about 461,258 (325)

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Application of a One-Step method for rapid detection of nucleic acids from fungi. [PDF]

Mycology
Yuan J, Qiao F, Chang W, Yang Y, Song L, Liu XL, Tian WX, Ren J, Liu X.   +8 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Correction: Ssengonzi et al. Inhibitor of DNA Binding Protein 2 (ID2) Mediates the Anti-Proliferative and Pro-Differentiation Effects of Insulin-like Growth Factor-1 (IGF-1). <i>Life</i> 2024, <i>14</i>, 1663. [PDF]

Life (Basel)
Ssengonzi R, Wang Y, Zhou J, Kayashima Y, Townley-Tilson WHD, Rao B, Ma Q, Maeda-Smithies N, Li F.   +8 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Iso-seq and RNA-seq data from ML-2 acute myeloid leukemia cells overexpressing the ZCCHC10 gene. [PDF]

Data Brief
Zhou H, Zhou J, Ning Y.
europepmc   +1 more source

Complete genome sequence of a <i>Kayfunavirus</i> bacteriophage identified in Blantyre, Malawi. [PDF]

Microbiol Resour Announc
Mhango C, Ndovie W, Zuza A, Chinyama E, Kawonga F, Matambo E, Kumwenda B, Kamng'ona AW, Chaguza C, Nyaga MM, Donato CM, Jere KC.   +11 more
europepmc   +1 more source

Metabolic Regulation of Influenza Vaccine Responses in Racially Diverse Hispanics. [PDF]

Vaccines (Basel)
Frasca D, Romero M, Pallikkuth S.
europepmc   +1 more source

Anti-inflammatory 25(OH)D₃, a natural steroid hormone, may complement all-trans retinoic acid therapy for differentiation syndrome in acute promyelocytic leukemia. [PDF]

Cell Death Dis
Jambrovics K, Al-Hadban W, Mázló-Türk A, Szatmari I, Dobó B, Reményi G, Jóna Á, Koncz G, Balajthy Z.   +8 more
europepmc   +1 more source

Assessment of Expression LncRNA-xloc-000303, lncRNA-LOC152578 and hsa-miR-29a in Patients Diagnosed With Colon Cancer in the Pre-Treatment Stage. [PDF]

Cancer Rep (Hoboken)
Tahami E, Akbari A, Nekouian R.
europepmc   +1 more source