Results 291 to 300 of about 463,109 (314)

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

microRNA Biomarkers in Paediatric Infection Diagnostics-Bridging the Gap Between Evidence and Clinical Application: A Scoping Review. [PDF]

Noncoding RNA
Rodgers O, De Beer A, Waterfield T.
europepmc   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Systematic review on biomarker potential of vitreous microRNA in retinal disease. [PDF]

Front Ophthalmol (Lausanne)
Joseph D, Grover B, Telias M.
europepmc   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Key virulence genes associated with <i>Streptococcus mutans</i> biofilm formation: a systematic review. [PDF]

Front Oral Health
Fitri DK, Tuygunov N, Wan Harun WHA, Purwasena IA, Cahyanto A, Zakaria MN.   +5 more
europepmc   +1 more source

Defining the kinetics of severe fever with thrombocytopenia syndrome virus acquisition and dissemination in naturally-infected <i>Haemaphysalis longicornis</i>. [PDF]

Front Cell Infect Microbiol
Esteves E, Obellianne C, Garba A, Sarkar SL, Schuler MG, Hermance ME.   +5 more
europepmc   +1 more source

DEFB4A/hBD2, a non-invasive serum biomarker for detection of ulcerative colitis. [PDF]

Sci Rep
Chatterjee S, Chakraborty A, Roy S, Roychowdhury D, Karmakar A, Saha A, Dhali GK, Banerjee S, Banerjee A.   +8 more
europepmc   +1 more source

The effects of graded hypoxia on gene expression related to oxygen sensing and metabolism. [PDF]

Sci Rep
Walker J, Ruby B, Slivka D.
europepmc   +1 more source

Molecular survey of the haemosporidians Haemoproteus and Leucocytozoon in Culicoides (Diptera: Ceratopogonidae) from the Brazilian Amazon. [PDF]

Rev Bras Parasitol Vet
Lee DAB, Pinto IS, Arantes PVC, Santarém MCA, Felippe-Bauer ML, Silva JVDSAD, Machado RZ, André MR.   +7 more
europepmc   +1 more source