Results 11 to 20 of about 317,876 (306)
Journal of Biological Chemistry, 1998 Introns interrupt the continuity of many eukaryal genes, and therefore their removal by splicing is a crucial step in gene expression. Interestingly, even within Eukarya there are at least four splicing mechanisms.
Abelson, John +2 more
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Methylated nucleosides in tRNA and tRNA methyltransferases [PDF]
Frontiers in Genetics, 2014 To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic pathways of the majority of tRNA modifications include a methylation step(s).
Hiroyuki eHori
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Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution [PDF]
Life, 2015 Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
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Extracellular tRNAs and tRNA-derived fragments [PDF]
RNA Biology, 2020 Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising ...
Juan Pablo Tosar, Alfonso Cayota
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Molecular Cell, 2005 Two recently published papers (Takano et al., 2005 and Shaheen and Hopper, 2005) demonstrate that in S. cerevisiae, cytoplasmic tRNAs can be transported into the nucleus. This retrograde movement may expose mature tRNAs to nuclear proofreading or it may regulate tRNA availability in response to amino acid availability.
Dahlberg, James, Lund, Elsebet
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tRNA Recognition by Glutamyl-tRNA Reductase [PDF]
Journal of Biological Chemistry, 2004 During the first step of porphyrin biosynthesis in Archaea, most bacteria, and in chloroplasts glutamyl-tRNA reductase (GluTR) catalyzes the NADPH-dependent reduction of glutamyl-tRNA to glutamate-1-semialdehyde. Elements in tRNA(Glu) important for utilization by Escherichia coli GluTR were determined by kinetic analysis of 51 variant transcripts of E.
Lennart, Randau +8 more
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tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation [PDF]
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life. Beyond translation control, tRFs have several functions ranging from transposon silencing to cell proliferation control.
Molla-Herman, Anahi +5 more
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Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs [PDF]
Nature Chemistry, 2018 Genetically encoding distinct non-canonical amino acids (ncAAs) into proteins synthesized in cells requires mutually orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The pyrrolysyl-tRNA synthetase/PyltRNA pair from Methanosarcina mazei (Mm) has been engineered to incorporate diverse ncAAs and is commonly considered an ideal pair for genetic code
Julian C. W. Willis, Jason W. Chin
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Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria. [PDF]
, 2016 BackgroundWhile the CCA sequence at the mature 3' end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H, Hou, Ya-Ming
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Phenylalanyl‐tRNA, Lysyl‐tRNA, Isoleucyl‐tRNA and Arginyl‐tRNA Synthetases [PDF]
European Journal of Biochemistry, 1980 Ten analogs of ATP have been tested in the ATP/PPi exchange reaction of Phenylalanyl‐tRNA, lysyl‐tRNA, isoleucyl‐tRNA and arginyl‐tRNA synthetases from baker's yeast. Three compounds are substrates for Phenylalanyl‐tRNA, seven for lysyl‐tRNA, two for isoleucyl‐tRNA and five for arginyl‐tRNA synthetase. Their Km and V values have been determined.
W, Freist, F, Cramer
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