Results 271 to 280 of about 345,668 (351)

Fyzika a česká státní maturita ve světle francouzských zkušeností

Pedagogická Orientace, 2018
Josef Trna
doaj  

Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases.

, 1987
Steven W. Ludmerer, Paul Schimmel
openalex   +1 more source

The complete mitochondrial genome of <i>Traccatichthys punctulatus</i> (Cypriniformes: Nemacheilidae) and its phylogenetic status. [PDF]

Mitochondrial DNA B Resour
Ni S, Di F, Huang S.
europepmc   +1 more source

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch. [PDF]

Nat Commun
Niu X, Cai S, Wang J, Chen C, Fang X.
europepmc   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, EarlyView.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Structural-guided identification of two modulators of β-1,3-glucan synthase FKS1. [PDF]

Nat Commun
Li J, Li J, Zhu A, Dai X, Liu J, Liu H, Xia Z, Dong Y, Qian W, Dai L, Guo L, Yan C, Deng D, Luo Y, Wang X.   +14 more
europepmc   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source