Results 271 to 280 of about 324,922 (336)

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Molecular characterization and phylogenetic analyses of the mitogenome of Wan-Xi white goose, a native goose breed in China. [PDF]

BMC Genom Data
Xia L, Bi S, Zhang Y, Chen C, Chen N.
europepmc   +1 more source

The monomeric glutamyl-tRNA synthetase of Escherichia coli. Purification and relation between its structural and catalytic properties.

, 1979
Daniel Kern, Serge Potier, Yves Boulanger, Jacques Lapointe   +3 more
openalex   +1 more source

NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation

Cell Proliferation, EarlyView.
NSun2 deficiency inhibited sinusoidal capillarization, alleviating liver fibrosis. Reduced NSun2 expression led to alterations in the functional tsRNAs tRF‐1‐S25 and tRF‐5‐V31, which regulate sinusoidal capillarization by targeting key proteins, including DUSP1 and FAK – crucial clinical targets – offering a novel RNA‐based therapeutic approach for ...
Pengcheng Li, Sunyang Ying, Yu Zou, Xin Wang, Runxue Zhang, Cheng Huang, Moyu Dai, Kai Xu, Guihai Feng, Xin Li, Haiping Jiang, Zhikun Li, Ying Zhang, Wei Li, Qi Zhou   +14 more
wiley   +1 more source

Emerging trends and hotspots of tRNA-derived small RNAs in tumours: a bibliometric analysis via VOSviewer and CiteSpace. [PDF]

Discov Oncol
Wang J, Shao EL, Gao Z.
europepmc   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Dynamic regulation of murine RNA polymerase III transcription during heat shock stress. [PDF]

Genetics
Nguyen TF, Kwan JZJ, Mitchell JE, Cui JH, Teves SS.   +4 more
europepmc   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Translation elongation: measurements and applications. [PDF]

RNA Biol
Watkins L, Li M, Wu B.
europepmc   +1 more source