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Analysis of tropane and related alkaloids

Journal of Chromatography A, 2002
The current methods for tropane alkaloid chromatographic separation and determination are summarised. The alkaloids included are: the medicinally applied tropic acid esters hyoscyamine and scopolamine and their derivatives, cocaine and derivatives, the metabolites and degradation products of these compounds occurring in plant material, calystegines as ...
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Conformation of Tropane Alkaloids

Nature, 1953
IT has become generally accepted that cyclohexane compounds1 and pyranosides2 possess the chair conformation. By analogy we may assume that piperidine and its derivatives also exist in the chair conformation. Starting from this assumption, it is possible to determine the conformation of tropane alkaloids.
AJAY K. BOSE, DILIP K. ROY CHAUDHURI
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Tropane alkaloids and toxicity of Convolvulus arvensis

Phytochemistry, 1995
Horses in a few, localized northern Colorado pastures exhibited weight loss and colic. At post mortem, intestinal fibrosis and vascular sclerosis of the small intestine was identified. The pastures where the affected horses grazed were overrun by field bindweed (Convolvulus arvensis). Bindweed from the pasture was found to contain the tropane alkaloids
F G, Todd   +4 more
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Tropane and Related Alkaloids

2000
Tropane alkaloids comprise a large group of bases occurring predominantly in the family of the Solanaceae. Structurally they are esters of carboxylic acids with tropine (3-hydroxy-8-aza-8-methyl-[3.2.1]-bicyclooctane) and are biosynthetically derived from amino acid and acetate precursors.
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Stereochemistry of the Tropane Alkaloids

Nature, 1952
THE respective C3-configurations of the epimeric N-acyl-nortropins have been recently established from the different behaviour of the epimers1 in acyl migration, N → O. Naturally occurring psi-tropine derivatives seem on this basis to contain a hydroxyl group syn-placed to the ring-nitrogen.
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Biosynthesis of Tropane Alkaloids

1989
As with other secondary products, the biosynthesis of tropane alkaloids in plants has been extensively investigated by the use of labelled precursors (for a review, see [11]). Recent advances in the techniques of alkaloid analysis and enzyme purification, however, have now made it possible to isolate and characterize biosynthetic enzymes in the pathway,
Y. Yamada, T. Hashimoto, T. Endo
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Tropane alkaloids in food

Tropane alkaloids (TAs) are known to be present in certain plants but can contaminate crops that enter the food chain, leading to severe toxic effects in humans. This has prompted the European Union to set legal limits for atropine and scopolamine, the most common TAs, in various foods.
Inês Parente   +4 more
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