Ultrasound-assisted extraction of scopolamine and hyoscyamine from Hyoscyamus niger roots using central compost design [PDF]
HeliyonHyoscyamus niger is an important medicinal plant used in medicine and contains tropane alkaloid compounds such as hyoscyamine and scopolamine. In this study, after the selection of the solvent for extracting hyoscyamine and scopolamine, the central ...
Roghayeh Ahmadpour +4 more
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Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants [PDF]
Plants, 2023 Tropane alkaloids (TAs) are large secondary metabolite alkaloids that find extensive applications in the synthesis of antidotes, anesthetics, antiemetics, motion sickness drugs, and antispasmodics.
Yuru Wen +5 more
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Bioorganic Chemistry, Toxinology, and Pharmaceutical Uses of Datura Metabolites and Derivatives [PDF]
ToxinsDatura species have been recognized for their potent pharmacological properties, producing a diverse array of tropane and non-tropane alkaloids with significant clinical and toxicological relevance.
Amin Mahmood Thawabteh +6 more
doaj +2 more sources
Chitosan nanoparticles as a strategy for enhancing h6h gene expression and tropane alkaloid production in Hyoscyamus reticulatus hairy roots [PDF]
Scientific ReportsHyoscyamus reticulatus L. is a rich source of tropane alkaloids (TA) which is widely used in medicine. In this study, hairy roots were obtained from two-week cotyledon explants of H. reticulatus L. by using the A7 strain of Agrobacterium rhizogenes.
Raheleh Godsi +2 more
doaj +2 more sources
Overproduction of tropane alkaloids in transgenic Hyoscyamus reticulatus hairy roots L. elicited by silicon dioxide nanoparticles and precursor feeding by phenylalanine and putrescine [PDF]
Scientific ReportsThe use of herbal medicines is expanding rapidly, and reputable pharmaceutical companies are increasing the proportion of effective herbal compounds in the production of drugs used to treat conditions such as cancer and neurological disorders.
Neda Hamdami +3 more
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Modeling the functionalized genistein-hyoscyamine derivatives [PDF]
Scientific ReportsDue to the significant rise in demand for functional foods and health-conscious alternatives, natural extracts present a promising avenue for exploration and application within the food processing sector.
Rana Abd-ElSalam +2 more
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Two-step epoxidation of hyoscyamine to scopolamine is catalyzed by bifunctional hyoscyamine 6β-hydroxylase [PDF]
FEBS Letters, 1993 In several solanaceous plants, hyoscyamine is first hydroxylated at the 6β‐position, and then epoxidized to scopolamine. We expressed hyoscyamine 6β‐hydroxylase (H6H) in Escherichia coli as a fusion protein with maltose‐binding protein. The crude cell extract from the bacterium that expressed the soluble fusion protein showed a strong hydroxylase ...
Yasuyuki Yamada
exaly +3 more sources
The high production of tropane alkaloids in hairy roots of Hyoscyamus reticulatus L. elicited by ZnO NPs in a bioreactor condition [PDF]
Scientific ReportsChemical synthesis issue of tropane alkaloids and their lowest production rate along with their extraction costs has made use of new methods necessary to produce valuable pharmaceutical compounds.
Sahar Alizadeh +3 more
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Elicitation of Hyoscyamine Production in Datura stramonium L. Plants Using Tobamoviruses
Plants, 2022 Datura stramonium L. produces tropane alkaloids, and the hyoscyamine is dominant among them. Hyoscyamine is produced by hairy root cultures in vitro derived from native plants or plants with the genetically modified biosynthetic pathway for hyoscyamine ...
Daniel Mihálik +4 more
doaj +1 more source
Effect of saccharides on secondary compounds production from stem derived callus of Datura inoxia
Biotechnology Reports, 2022 Datura inoxia is a subshrub plant known for its toxicity which results from the presence of the tropane alkaloid scopolamine and hyoscyamine. Saccharides are one of the most important elicitors that can alter physiological and biochemical responses in ...
Baan Munim Twaij +3 more
doaj +1 more source