Results 31 to 40 of about 2,915 (202)

Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants

Frontiers in Plant Science, 2022
Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low in planta.
Haiyue Gong, Ping He, Xiaozhong Lan, Lingjiang Zeng, Zhihua Liao, Zhihua Liao   +5 more
doaj   +1 more source

Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium [PDF]

E3S Web of Conferences, 2021
The alkaloid extract of datura stramonium (rich of atropine, hyoscyamine, scopolamine) is used to evaluate its effect on the central nervous system in rats (locomotion, anxiety).
Didou Latifa, Azzaoui Fatima-Zahra, Ahami Ahmed omar touhami, Ed-Day Soumia, Kacimi Fatima Ezzahra, Boulbaroud Samira   +5 more
doaj   +1 more source

Application of Metabolic Engineering to the Production of Scopolamine

Molecules, 2008
Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular
Mohammad Hossein Mirjalili, Liliana Hernandez-Vazquez, Arturo Navarro-Ocaña, Javier Palazón   +3 more
doaj   +1 more source

Enhancement of Growth and Alkaloids Accumulation in Hyoscyamus muticus L. Callus Cultures by High Salt Concentration [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2019
The effect of different concentrations of NaCl (6, 8 and 10 dS/m) on growth and alkaloids production in 21 days-old callus of Egyptian henbane (Hyoscyamu muticus L.) was studied.
Akram Abuseidah, Elham Ali, Islam Abuelsoud, Enas Eltamany, Mohamed El-hamahmy, Eman Abdelrazik   +5 more
doaj   +1 more source

Variations in morphological, biochemical and phytochemical traits of diploid and induced tetraploid plants of downy thorn-apple (Datura innoxia Mill.)

Journal of Medicinal Plants, 2022
Background: Datura species produce a wide range of tropane alkaloids with medicinal values. D. innoxia is a species of the Datura genus which is poisonous and has an unpleasant odor due to the presence of tropane alkaloids.
Parisa Naderian, Nasrin Moshtaghi, Abdolreza Bagheri, Saeed Malekzade Shafaroudi   +3 more
doaj  

EFFECT OF PUTRESCINE AND PHENYLALANINE ON GROWTH, AND ALKALOID PRODUCTION OF SOME Datura species. [PDF]

Journal of Soil Sciences and Agricultural Engineering, 2004
Two field experiments were carried out at the Experimental Farm of Cultivation and Production of Medicinal and Aromatic Plants Dept. National Research Centre at Giza, during two successive seasons, to study the effect of foliar application of two ...
M. S. Abd EI Wahed, R. A. EI-Mergawi, A. A. Youssef   +2 more
doaj   +1 more source

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

Nature Communications, 2023
Tropane alkaloids (TAs) are synthesized by some species in Solanaceae. Here, the authors assemble the genomes of two representative TAs producing species, show that gene loss shapes uneven distribution of TAs in Solanaceae, and identify a cytochrome P450
Fangyuan Zhang, Fei Qiu, Junlan Zeng, Zhichao Xu, Yueli Tang, Tengfei Zhao, Yuqin Gou, Fei Su, Shiyi Wang, Xiuli Sun, Zheyong Xue, Weixing Wang, Chunxian Yang, Lingjiang Zeng, Xiaozhong Lan, Min Chen, Junhui Zhou, Zhihua Liao   +17 more
doaj   +1 more source

A non-aqueous solid phase extraction method for alkaloid enrichment and its application in the determination of hyoscyamine and scopolamine

, 2012
A non-aqueous solid phase extraction (SPE) method utilizing silica based strong cation exchange (SCX) was developed and optimized for the enrichment of alkaloids.
Wang, Chaoran, Zeng, Jing, Nordahl, Lilly, Liang, Xinmiao, Long, Zhen, 梁鑫淼, Guo, Zhimou, Zhang, Xiuli, Zeng, Jianguo, 张秀莉   +9 more
core   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, Volume 18, Issue 9, Page 1005-1015, September 2026.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

A small-scale proteomic approach reveals a survival strategy, including a reduction in alkaloid biosynthesis, in Hyoscyamus albus roots subjected to iron deficiency

Frontiers in Plant Science, 2013
Hyoscyamus albus is a well-known source of the tropane alkaloids, hyoscyamine and scopolamine, which are biosynthesized in the roots. To assess the major biochemical adaptations that occur in the roots of this plant in response to iron deficiency, we ...
Jebunnahar eKhandakar, Izumi eHaraguchi, Kenichi eYamaguchi, Kenichi eYamaguchi, Kenichi eYamaguchi, Yoshie eKitamura, Yoshie eKitamura   +6 more
doaj   +1 more source