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Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, Volume 15, Issue 4, April 2026.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Research of change of tropane alkaloids quantities in different stages of growth of Hyoscyamus reticulatus L. in natural condition and assessment of suger and elements changes on biosynthesis of these alkaloids in In vitro

Journal of Medicinal Plants, 2004
Hyoscyamus reticudatus from Solanaceae is an important pharmacological plant which contains tropane alkaloids. Presence of tropane alkaloids in this plant is investigated by HPLC apparatus.
F Chalabian, A Majd
doaj  

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source

Quantitative Assessment of Hyoscyamine and Scopolamine Tropane Alkaloids in Root and Shoot of Hyoscyamus spp. from Iran

Journal of Medicinal Plants, 2015
Background: Different species of Hyoscymaus are rich sources of tropane alkaloids, especially hyoscyamine and scopolamine. These compounds medicinally are important tropane alkaloids that exclusively are produced by plants.
F Fattahi, A Shojaeiyan, H Askari, H Naghdi Badi, Ayyari M, Mokhtassi-Bidgoli A, Palazon Barandela J   +6 more
doaj  

Cultivation of diploid and tetraploid hairy roots of Datura stramonium L. in stirred tank bioreactor for tropane alkaloids production [PDF]

Journal of BioScience and Biotechnology, 2012
Biomass accumulation and tropane alkaloids production by diploid and tetraploid hairy root cultures of Datura stramonium L. cultivated in stirred tank bioreactor at different aeration rates were investigated.
ATANAS PAVLOV, IVAN IVANOV, VASIL GEORGIEV, ANDREY MARCHEV   +3 more
doaj  

Mycotoxins in plant‐based drinks (soy, almond and oat): the BfR updates its assessment of their health risks based on newly collected data

Food Risk Assess Europe, Volume 4, Issue 2, April 2026.
Abstract Mycotoxins (mould toxins) are secondary metabolites of moulds. They are natural toxins whose occurrence in food and feed is undesirable but cannot be completely avoided. Mycotoxins may occur as contaminants in plant products and raw materials such as grains, nuts and almonds if they are infested with mould during cultivation, storage or ...
German Federal Institute for Risk Assessment (BfR)
wiley   +1 more source

Synergistic effects of polyploidization and elicitation on biomass and hyoscyamine content in hairy roots of Datura stramonium

Biotechnologie, Agronomie, Société et Environnement, 2016
Description of the subject. The hyoscyamine, a tropane alkaloid, widely used in medicine, can be produced from Datura sp. (Solanaceae). However, its content in the spontaneous roots remains low; therefore, hairy roots (HRs) were envisaged as a potential ...
Belabbassi, O., Khelifi-Slaoui, M., Zaoui, D., Benyammi, R., Khalfallah, N., Malik, S., Makhzoum, A., Khelifi, L.   +7 more
doaj  

Machine Learning Integration Framework Constructs a Lactylation‐Associated Gene Signature to Improve Prognosis in Bladder Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang, Qianxue Lu, Panpan Jiao, Jun Jian, Qingyuan Zheng, Zhiyuan Chen, Xiuheng Liu, Shanshan Wan, Lei Wang   +8 more
wiley   +1 more source

Assessment of the Conclusions of the Joint FAO/WHO Expert Meeting on Tropane Alkaloids

EFSA Journal, 2022
The European Food Safety Authority (EFSA) was requested to assess the differences in the outcome of the risk assessment of tropane alkaloids (TAs) in food between the CONTAM Panel and the Joint FAO/WHO meeting (FAO/WHO) and to conclude if an update of ...
European Food Safety Authority (EFSA), Marco Binaglia   +1 more
doaj   +1 more source

Exposure the Hazardous Potential of Quinalphos: An In‐Depth Analysis for Environmental and Biological Effects on Human Health

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari, Biju Prava Sahariah, Anand Kumar Jayapal, Jyotsna Choubey, Abhishek Tripathi   +4 more
wiley   +1 more source