Results 61 to 70 of about 2,915 (202)

A novel medical protocol to treat uterotubal spasm during Essure hysteroscopic sterilization: a pilot study

Open Access Journal of Contraception, 2012
Hector O Chapa,1 Gonzalo Venegas21Women's Specialty Center, Dallas, TX, USA; 2Clinical Faculty, Department ObGyn Methodist Medical Center, Dallas, TX, USAObjective: To evaluate sublingual hyoscyamine (0.125 mg) as a uterotubal spasm reliever to ...
Chapa HO, Venegas G
doaj  

Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis

Nature Communications, 2022
Cocaine is a tropane alkaloid produced by Erythroxylum novogranatense. Here the authors identify two polyketide synthases involved in cocaine biosynthesis and provide insight into the parallel evolution of these enzymes in tropane alkaloids-producing ...
Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Jie Li, Bingyan Xu, Yin Chen, Li Wang, Jing Yang, Yijun Yan, Sheng-Xiong Huang   +9 more
doaj   +1 more source

Overview of acute Chinese medicine poisoning in Hong Kong

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 6, December 2025.
Abstract Background Chinese medicine (CM) poisoning is relatively rare in Hong Kong. According to the Department of Health, only 17 cases of self‐medicated Traditional Chinese Medicine (TCM)‐related poisoning were reported between 2019 and 2021—an average of approximately 5.7 cases per year.
Siu Kan Law, Yanping Wang, Xiao Xiao Wu
wiley   +1 more source

High‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Background Medications associated with acute liver injury (ALI) are primarily identified by case reports. High‐throughput screening of real‐world data could be leveraged to detect hepatotoxicity signals. Objective To apply tree‐based scan statistics in real‐world data to identify drugs associated with hospitalization for severe ALI among ...
Vincent Lo Re III, Craig W. Newcomb, Dean M. Carbonari, Charles E. Leonard, Christopher T. Rentsch, Judith C. Maro   +5 more
wiley   +1 more source

Biochemical and structural characterization of recombinant hyoscyamine 6 beta-hydroxylase from Datura metel L.

, 2010
Hyoscyamine 6 beta-hydroxylase (H6H; EC 1.14.11.11), an important enzyme in the biosynthesis of tropane alkaloids, catalyzes the hydroxylation of hyoscyamine to give 6 beta-hydroxyhyoscyamine and its epoxidation in the biosynthetic pathway leading to ...
Pramod, KK, Singh, Satpal, Jayabaskaran, C, C. Jayabaskaran, Satpal Singh, K.K. Pramod   +5 more
core   +1 more source

Quantitative analysis of total alkaloids by titration and Hyoscyamine by HPLC in indigenous Datur species inNorth of Iran [PDF]

Journal of Mazandaran University of Medical Sciences, 2005
Background and purpose :.There are ten identified species of Datura in the world. Datura stramonium L. (Torn apple or Jimsonweed) and D.innoxia Mill. (Hindudatura) are endemic species of Datura in Iran, especially in the North (Caspian Sea region).
M. Azadbakht, S.M. Hoseinzadeh
doaj  

Concurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Purpose Anticholinergic medications and alcohol each independently increase the risk of community‐acquired pneumonia (CAP). Whether non‐anticholinergic neurocognitively active medications also increase risk, and if alcohol modifies these associations, remains unclear. Methods We conducted a nested case–control study using Veterans Aging Cohort
William H. Wang, Kristina Crothers, Kathleen M. Akgün, Kirsha S. Gordon, Maria C. Rodriguez‐Barradas, Julie A. Womack, Jennifer Thompson, Amy C. Justice, Christopher T. Rentsch   +8 more
wiley   +1 more source

The study of hyoscyamine in oxidative stress of liver cells in male rat [PDF]

, 2017
Background and aims: Increased production of free radicals by endogenous systems and exogenous sources in cells leads to oxidative stress, which damages to the cells of various organs.
Khosravi Farsani, Nariman., Amini Farsani, Zeinab., Teimori, Hossein., Mashhadi Akbar Boojar, Masoud., Gholami, Delnia., Sajadpoor, Zahra.   +5 more
core   +1 more source

Hyoscyamine-producing marine Actinomycetes from Lagos Lagoon sediment

Asian Pacific Journal of Tropical Biomedicine, 2015
Objective: To isolate and screen Actinomycetes from Lagos Lagoon soil sediments for production of bioactive metabolites. Methods: Sediment samples were collected from four different locations of Lagos Lagoon and were dried for 2 weeks after which the ...
Davies Olabisi Flora, Adeleye Isaac Adeyemi, Wang Peng George   +2 more
doaj   +1 more source

Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts

Plant Biology, Volume 27, Issue 7, Page 1378-1390, December 2025.
Indian heliotrope uses the same oxidase to produce complex pyrrolizidine alkaloid esters in aerial parts and simple pyrrolizidine alkaloids in roots. Abstract Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites found in several plant lineages with independent evolutionary origins.
M. M. Zakaria, M.‐B. Salewski, D. Ober
wiley   +1 more source